16954-74-8Relevant articles and documents
One-pot of three-component synthesis of novel amino-spiroindene derivatives
Darehkordi, Ali,Karimi-Taleghani, Zahra,Pouralimardan, Omid Ali
, p. 623 - 629 (2014)
A facile and efficient one-pot three-component synthesis of the amino-spiroindene derivatives was achieved, via the reaction of ninhydrin, malononitrile or ethylcyanoacetate and various reagents including 1, 2- and 1,3-dicarbonyl compounds/enols. Graphical Abstract: [Figure not available: see fulltext.].
Introducing new method for the synthesis of polycyclic compounds containing [1,3]dithiine derivatives, with anticancer and antibacterial activities against common bacterial strains between aquatic and human
Moghaddam-Manesh, Mohammadreza,Hosseinzadegan, Sara
, p. 2174 - 2180 (2021)
In this study, glycerol:potassium carbonate used as a green deep eutectic solvent, for synthesis of polycyclic compounds containing [1,3]dithiine derivatives. The antimicrobial properties of the derivatives against Lactococcus garvieae and Edwardsiella tarda were tested as bacterial strains between aquatic and human based on the minimum inhibitory concentration (MIC), the minimum lethal concentration (MBC) and inhibition zone diameter (IZD). In addition to antimicrobial properties, cytotoxicity testing was performed against MCF-7 breast cancer cells via MTT cell viability assay.
Amine-promoted one-pot, Multicomponent route to spiro-fused-pyran derivatives in aqueous media
Alizadeh, Abdolali,Rezvanian, Atieh,Bayat, Fahimeh
, p. 532 - 536 (2014)
The primary amine-promoted synthesis of spiro-fused-pyran derivatives via the three-component reaction of ninhydrin, malononitrile, and cyclic 1,3-diketo compounds is described. This new methodology affords the title compounds in high yields and short time, and with easy workup without chromatographic purification steps or extraction. All structures were confirmed by IR, 1H- and 13C-NMR spectroscopy, and mass spectroscopy. A plausible mechanism for this type of reaction is proposed (Scheme 2). Copyright
Facile one pot microwave assisted solvent-free synthesis of novel spiro-fused pyran derivatives via the three-component condensation of ninhydrin with malononitrile and active methylene compounds
Shaker, Raafat M.,Mahmoud, Alaa F.,Abdel-Latif, Fathy F.
, p. 563 - 567 (2005)
Three-component condensation of ninhydrin, malononitrile, and some nucleophilic reagents in the presence of piperidine under microwave irradiation without solvent afforded the corresponding spiro-fused pyran derivatives. The structures of the products were proved by elemental analyses, IR, 1H NMR and MS spectroscopy.
Synthesis, characterization and antimicrobial evaluation of novel 6'-amino-spiro[indeno[1,2-b] quinoxaline[1,3]dithiine]-5'-carbonitrile derivatives
Akhgar, Mohammadreza,Ghazanfari, Dadkhoda,Moghaddam-Manesh, Mohammadreza,Sheikhhosseini, Enayatollah
, p. 276 - 282 (2020/04/01)
l,3-Dithiin with two sulfurs in its structure is a six-membered, sulfur-containing heterocyclic compound. New derivatives of 6'-amino-2'-(arylidene)spiro[indeno[1,2-b]quinoxaline[1,3]dithiine]-5'-carbonitrile were prepared by the multi-component reaction of active methylene compounds, carbon disulfide, malononitrile and multi-ring compounds containing a carbonyl group in the presence of piperidine as a catalyst at room temperature with high efficiency. The antimicrobial effects including antibacterial and antifungal effects based on inhibition zone diameter (IZD), minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were studied.
Synthesis method of 1,4-dyhydroxyl-2,3-naphthyldinitrile and derivative thereof
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Paragraph 0033; 0034, (2017/07/04)
The invention discloses a synthesis method of 1,4-dyhydroxyl-2,3-naphthyldinitrile and a derivative thereof. The method takes ninhydrin and a derivative thereof as raw materials, and the ninhydrin and the derivative thereof react with malononitrile in water to generate 2-(dicyanomethylene)indene-1,3-diketone and a derivative thereof; the 2-(dicyanomethylene)indene-1,3-diketone and the derivative thereof further react with anhydrous potassium iodide and are isomerized to generate potassium salt of the 1,4-dyhydroxyl-2,3-naphthyldinitrile; and after the potassium salt of the 1,4-dyhydroxyl-2,3-naphthyldinitrile is acidified and then is separated, the high-purity product (the 1,4-dyhydroxyl-2,3-naphthyldinitrile) is obtained. The method disclosed by the invention has the advantages of wide raw material resource and low price; the cost is low and the method is green and environmentally friendly; and the method is convenient for industrialized large-scale production.