1695533-89-1 Usage
Description
KO947 is an ERK inhibitor (IC50 = <50 nM for ERK2). It is greater than 50-fold selective for ERK over a panel of 450 kinases. KO947 reduces phosphorylation of the ERK target p90 ribosomal S6 kinase (RSK) in A375 cancer cells containing constitutively active B-RAFV600E with an IC50 value of less than 250 nM. It inhibits proliferation of A375 cells, as well as mutant K-Ras-expressing HCT116 and H358 cancer cell lines (IC50s = 50-250 nM for all).
Check Digit Verification of cas no
The CAS Registry Mumber 1695533-89-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,9,5,5,3 and 3 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1695533-89:
(9*1)+(8*6)+(7*9)+(6*5)+(5*5)+(4*3)+(3*3)+(2*8)+(1*9)=221
221 % 10 = 1
So 1695533-89-1 is a valid CAS Registry Number.
1695533-89-1Relevant articles and documents
INHIBITORS OF ERK AND METHODS OF USE
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, (2015/04/22)
The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as ERK (MAPK). Also provided are methods of using such compounds or compositions, and methods of using these compositions to modulate the activities of one or more of these kinases, especially for therapeutic applications such as the treatment disorders such as cancer.
