16957-97-4Relevant articles and documents
-
Bordwell,Albisetti
, p. 1955,1957 (1948)
-
Bis(diphenylamino)-benzo[4,5]thieno[3,2-b]benzofuran as hole transport material for highly efficient RGB organic light-emitting diodes with low efficiency roll-off and long lifetime
Ali, Muhammad Umair,Fang, Daqi,He, Yaowu,Meng, Hong,Miao, Jingsheng,Shi, Ming,Sun, Yue,Wang, Tao,Wang, Yunrui,Zhang, Tian
, (2020)
In this work, a novel hole transport material (HTM) based on benzo[4,5]thieno[3,2-b]benzofuran (BTBF) core with diphenylamine group, BTBF-DPA, was synthesized and systematically studied. BTBF-DPA showed high carrier mobility, good thermal stability and high triplet energy as 2.99 eV. Green phosphorescent organic light-emitting diodes (PhOLEDs) using BTBF-DPA were fabricated which displayed outstanding electroluminescent performance with a low turn-on voltage of 2.4 V, the maximum current efficiency (CE) of 123.6 cd A?1, power efficiency (PE) of 136.6 lm W?1, and external quantum efficiency (EQE) of 34.1%. Red PhOLEDs with BTBF-DPA also demonstrated a maximum PE of 40.1 lm W?1, and EQE of 24.9% with a low turn-on voltage of 2.3 V. Besides, blue fluorescence OLEDs presented a maximum PE of 4.9 lm W?1, EQE of 5.2% and small efficiency roll-off of 11.5% at 10000 cd m?2. RGB-OLEDs with BTBF-DPA outperformed the reference devices based on NPB as HTM that has been widely utilized. What's more, life-time of RGB OLEDs were T99 = 70 h at 10000 cd m?2, T70 = 60 h at 10000 cd m?2, T80 = 125 h at 5000 cd m?2, respectively. These results imply that BTBF-DPA is a promising HTM for OLEDs.
Discovery of a Potent and Orally Bioavailable Hypoxia-Inducible Factor 2α (HIF-2α) Agonist and Its Synergistic Therapy with Prolyl Hydroxylase Inhibitors for the Treatment of Renal Anemia
Yu, Yancheng,Yang, Fulai,Yu, Quanwei,Liu, Simeng,Wu, Chenyang,Su, Kaijun,Yang, Le,Bao, Xiaoqian,Li, Zhihong,Li, Xiang,Zhang, Xiaojin
, p. 17384 - 17402 (2021/11/16)
Activation of hypoxia-inducible factor 2 (HIF-2) has emerged as a potent renal anemia treatment strategy. Here, the benzisothiazole derivative 26 was discovered as a novel HIF-2α agonist, which first demonstrated nanomolar activity (EC50 = 490 nM, Emax = 349.2%) in the luciferase reporter gene assay. Molecular dynamics simulations indicated that 26 could allosterically enhance HIF-2 dimerization. Furthermore, compound 26 had a good pharmacokinetic profile (the oral bioavailability in rats was 41.38%) and an in vivo safety profile (the LD50 in mice was greater than 708 mg·kg-1). In the in vivo efficacy assays, the combination of 26 and the prolyl hydroxylase inhibitor, AKB-6548, was confirmed for the first time to synergistically increase the plasma erythropoietin level in mice (from 260 to 2296 pg·mL-1) and alleviate zebrafish anemia induced by doxorubicin. These results provide new insights for HIF-2α agonists and the treatment of renal anemia.
Synthesis of Polysubstituted Iodoarenes Enabled by Iterative Iodine-Directed para and ortho C?H Functionalization
Wu, Yichen,Bouvet, Sébastien,Izquierdo, Susana,Shafir, Alexandr
supporting information, p. 2617 - 2621 (2019/01/04)
Among halogenated aromatics, iodoarenes are unique in their ability to produce the bench-stable halogen(III) form. Earlier, such iodine(III) centers were shown to enable C?H functionalization ortho to iodine via halogen-centered rearrangement. The broader implications of this phenomenon are explored by testing the extent of an unusual iodane-directed para C?H benzylation, as well as by developing an efficient C?H coupling with sulfonyl-substituted allylic silanes. Through the combination of the one-shot nature of the coupling event and the iodine retention, multisubstituted arenes can be prepared by sequentially engaging up to three aromatic C?H sites. This type of iodine-based iterative synthesis will serve as a tool for the formation of value-added aromatic cores.
