169601-80-3Relevant academic research and scientific papers
5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
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, (2008/06/13)
The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the tre
5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
-
, (2008/06/13)
The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the tre
6-Phenyl-6-alkylamido-5,6-dihydro-2H-pyran-2-ones: Novel HIV protease inhibitors
Hamilton, Harriet W.,Tait, Bradley D.,Gajda, Christopher,Hagen, Susan E.,Ferguson, Donna,Lunney, Elizabeth A.,Pavlovsky, Alexander,Tummino, Peter J.
, p. 719 - 724 (2007/10/03)
Publications from our laboratories have recently described a series of 3-thioaryl substituted-4-hydroxy-pyrones as HIV protease inhibitors. The current work examines the analogues 5,6-dihydro-2H-pyran-2-ones with 6,6-substitutions focusing on the use of 1
