169611-43-2Relevant articles and documents
Enantioselective Borane Reduction of Acetophenone Catalysed by Oxazaborolidines Derived from Chiral Diethanolamines
Dubois, Laurent,Fiaud, Jean-Claude,Kagan, Henri B.
, p. 1097 - 1104 (1995)
The synthesis of oxazaborolidines of types 1 and 2, derived from chiral diethanolamines and their behaviour, as catalysts for the asymmetric reduction of acetophenone by borane has been investigated.Bicyclic oxazaborolidines of type 2 afforded the expected alcohol in good yield but with modest ee's (ee40percent).Monocyclic oxazaborolidines of type 1 gave better results.For instance, catalyst 16 allowed the isolation of (S) α-methyl benzyl alcohol with 72percent ee while oxazaborolidine 26, structurally close to 16, produced a remarkable reversal of enantiofacial selectivity.The origin of the enantioselectivity of these catalysts is discussed on the basis of transition state models.
2 Tyrosine kinase mediated signal transduction inhibitors
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Paragraph 0556; 0557; 0559, (2019/09/17)
Disclosed herein are compounds of Formula (), and pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, X, X, X, X, X, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.
