169619-83-4Relevant academic research and scientific papers
COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
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Page/Page column 74-75, (2008/12/07)
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
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Page/Page column 68-69, (2008/06/13)
The present invention discloses compounds of Formula I: (I) having 11beta -HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Fomula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.
An Efficient and Highly Chemoselective Method to Desilylate Silyl Ethers
Lee, Adam Shih-Yuan,Yeh, Hsiu-Chih,Yeh, Ming-Kuo,Tsai, Ming-Hung
, p. 919 - 922 (2007/10/03)
An efficient and highly chemoselective desilylating method is described.Trimethylsilyl ethers (0.25 M) in a CH3OH/CCl4 (1:1) solvent mixture are deprotected to their corresponding alcohols with ultrasound in a commercial ultrasonic cleaning bath.Selective deprotection of tert-butyldimethylsilyl ethers of benzyl alcohols and phenols is achieved under ultrasonic conditions.We deprotected also tert-butyldimethylsilyl ethers of primary alcohols, whereas tert-butyldimethylsilyl ethers of secondary and tertiary alcohols are stable under these conditions. - Key words: Sonochemistry; Ultrasound; Cavitation; Desilylation; Chemoselection; Deprotection.
