16964-21-9Relevant academic research and scientific papers
Identification of N -phenyl-2-(N -phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation
Song, Yu,Xue, Xiaoqian,Wu, Xishan,Wang, Rui,Xing, Yanli,Yan, Weiqun,Zhou, Yulai,Qian, Chao-Nan,Zhang, Yan,Xu, Yong
, p. 13 - 26 (2016/04/19)
Retinoic acid receptor-related orphan receptors (RORs) are ligand-dependent transcriptional factors and members of the nuclear receptor superfamily. RORs regulate inflammation, metabolic disorders and circadian rhythm. RORγ is a promising therapeutic drug
Antibacterially Active Substituted Anilides of Carboxylic and Sulfonic Acids
Linfield, Warner M.,Micich, Thomas J.,Montville, Thomas J.,Simon, John R.,Murray, Ermellina B.,Bistline, Raymond G.
, p. 1741 - 1746 (2007/10/02)
Anilides of carboxylic and sulfonic acids were prepared and tested for antimicrobial activity.While these anilides were ineffective against Gram-negative organisms, there was good correlation between chemical structure and biological activity against Gram-positive species.Both the nature and position of the benzene ring substituents and the length of the carbon side chain affected the activity and specificity of the compounds.The highest activity was observed when the acyl or sulfuryl moiety had a C7-C9 side chain attached.The CONH and SO2NH bridging groups wereequally effective.The attachment of COOH or COOCH3 groups in the ω-position did not effect activity, but the substitution of the acidic proton of the sulfonamide group by an alkyl group rendered the compound inactive.Six compounds, which were substituted anilides of sulfonic acids, fatty acids, or the analogues α-methylene-substituted acids, were bacteriostatic at 10 ppm against Bacillus cereus, Staphylococcus aureus, Streptococcus faecalis and Lactobacillus plantarum .One of these compounds, 2-hydroxy-5-nitroanilide of α-methylenedecanoic acid, was bactericidal at 1 ppm.
