16966-09-9

Basic information

• Product Name: Z-THR(TBU)-OH
• Synonyms: Z-THR(TBU)-OH;(2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid;L-Threonine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-;Cbz-Thr(tBu)-OH
• CAS NO: 16966-09-9
• Molecular Formula: C₁₆H₂₃NO₅
• Molecular Weight: 309.35752
• Mol File: 16966-09-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 470.1°C at 760 mmHg
• Flash Point: 238.1°C
• Appearance: /
• Density: 1.152g/cm³
• Vapor Pressure: 1.22E-09mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Z-THR(TBU)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-THR(TBU)-OH(16966-09-9)
• EPA Substance Registry System: Z-THR(TBU)-OH(16966-09-9)

Safety Data

• Hazardous Substances Data: 16966-09-9(Hazardous Substances Data)

Usage

General Description

Z-THR(TBU)-OH is a chemical compound commonly used in organic synthesis and pharmaceutical research. It is a derivative of the amino acid threonine, and is often utilized in the creation of peptide-based drugs and molecules. The "Z" in its name indicates a protective group attached to the threonine, which can be removed later in the synthesis process. The "TBU" stands for tert-butyl, a common functional group in organic chemistry. Z-THR(TBU)-OH is important for its role in the development of new drugs and bioactive molecules, and is a valuable tool for researchers in the field of chemical biology.

InChI:InChI=1/C16H23NO5/c1-11(22-16(2,3)4)13(14(18)19)17-15(20)21-10-12-8-6-5-7-9-12/h5-9,11,13H,10H2,1-4H3,(H,17,20)(H,18,19)/t11?,13-/m0/s1

Upstream product

• 16879-87-1 p-Nitrobenzyl N-Benzyloxycarbonyl-(O-t-Butyl) Threoninate 
• 16879-84-8 N-(benzyloxycarbonyl)-L-threonine p-nitrobenzyl ester 
• 83824-81-1 (2S,3S)-3-methylaziridine-1,2-dicarboxylic acid 1-benzylester 2-methyl ester 
• 57224-63-2 methyl (2S,3R)-2-(benzyloxycarbonylamino)-3-hydroxybutyrate 
• 14437-51-5 N-Carbobenzoxy-O-tert.-butyl-L-threonin-tert.-butylester 
• 16966-07-7 (2S,3R)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid dicyclohexylammonium salt 
• 52785-41-8 N-benzyloxycarbonyl-O-tert-butylthreonine methyl ester 
• 57224-63-2 Z-DL-aThr-OMe 
• 52785-41-8 Z-DL-aThr(t-Bu)-OMe 
• 501-53-1 benzyl chloroformate 
• 57224-63-2 Z-DL-Thr-OMe 
• 52785-41-8 Z-DL-Thr(t-Bu)-OMe 
• 4378-13-6 (O-tert-butyl)-L-threonine 
• 19728-63-3 N-benzyloxycarbonyl-L-treonine 

Downstream Products

• 27981-26-6 (R)-2-[(1R,2S)-2-((2S,3R)-2-Benzyloxycarbonylamino-3-tert-butoxy-butyryloxy)-1-(3-methyl-butyryloxy)-propyl]-hexanoic acid tert-butyl ester 
• 27981-26-6 (S)-2-[(1S,2R)-2-((2S,3R)-2-Benzyloxycarbonylamino-3-tert-butoxy-butyryloxy)-1-(3-methyl-butyryloxy)-propyl]-hexanoic acid tert-butyl ester 
• 183742-71-4 (2S,3S,4S,5R,6R)-3,4,5-Triacetoxy-6-((2S,3R)-2-benzyloxycarbonylamino-3-tert-butoxy-butyrylamino)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 16966-07-7 (2S,3R)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid dicyclohexylammonium salt 
• 1202236-71-2 benzyl N-[(1S,2R)-2-tert-butoxy-1-(tert-butoxycarbamoyl)propyl]carbamate 
• 116857-33-1 Z-Thr(tBu)-Ala-OH 
• 116857-32-0 methyl ((benzyloxy)carbonyl)-L-(O-tert-butyl)threonyl-L-alaninate 

Relevant articles and documents

COMPOUNDS USEFUL FOR THE TREATMENT OF INFECTION WITH MANNHEIMIA HAEMOLYTICA OR HISTOPHILUS SOMNI

The present invention discloses compounds that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD)

Efficient and practical procedure for the esterification of the free α-carboxylic acid of amino acid residues with β-(trimethylsilyl)ethoxymethyl chloride and triisopropylsilyl chloride

An efficient and practical procedure for the free α-carboxylic acid esterification of amino acid residues with β-(trimethylsilyl)ethoxymethyl chloride and triisopropylsilyl chloride is described. The reaction takes place under mild conditions and the expected protected amino acids are obtained in good to excellent yields. Our method provides a useful alternative for the C-terminal carboxylic acid protection of amino acids and peptides. Moreover, the removal of such protection was also achieved under mild conditions, without affecting either the other protecting groups at the α-amino moiety and side chains or the optical integrity at the α-position of the amino acid residues. Examples of their use in peptide synthesis are also illustrated.

Structure elucidation of the peptide antibiotics herbicolin A and B

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