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169675-09-6

(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE, also known as Ro 60-0175 fumarate, is a potent and selective agonist of the serotonin (5-HT) receptor subtype 5-HT2. It effectively stimulates increases in intracellular calcium levels in cells expressing human 5-HT2A, 5-HT2B, and 5-HT2C receptors. Ro 60-0175 fumarate demonstrates high selectivity for human 5-HT2A and 5-HT2C receptors over various other receptors, including adenosine, histamine, dopamine, adrenergic, muscarinic, nicotinic, kainate, AMPA, and opioid receptors. Additionally, it exhibits the ability to increase plasma levels of corticosterone, oxytocin, and prolactin in rats.

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  • Ro 60-0175 fumarate,(αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanaminefumarate

    Cas No: 169675-09-6

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  • 169675-09-6 Structure

  • Basic information

    1. Product Name: (AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE
    2. Synonyms: RO 60-0175 FUMARATE;(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE;(alpha-S)-6-Chloro-5-fluoro-alpha-methyl-(1H)-indole-1-ethaneaminefumarate;(S)-2-(Chloro-5-fluoro-indol-L-yl)-1-methylethylamine fumarate;1H-Indole-1-ethanamine, 6-chloro-5-fluoro-alpha-methyl-, (alphas)-, (2E)-2-butenedioate (1:1);1H-Indole-1-ethanamine, 6-chloro-5-fluoro-alpha-methyl-, (S)-, (E)-2-butenedioate (1:1);(αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanaminefumarate;1H-Indole-1-ethanaMine, 6-chloro-5-fluoro-a-Methyl-, (aS)-, (2E)-2-butenedioate
    3. CAS NO:169675-09-6
    4. Molecular Formula: C15H16ClFN2O4
    5. Molecular Weight: 342.75
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 169675-09-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 353.2°Cat760mmHg
    3. Flash Point: 167.4°C
    4. Appearance: /
    5. Density: g/cm3
    6. Vapor Pressure: 3.65E-05mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Desiccate at RT
    9. Solubility: N/A
    10. CAS DataBase Reference: (AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE(CAS DataBase Reference)
    11. NIST Chemistry Reference: (AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE(169675-09-6)
    12. EPA Substance Registry System: (AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE(169675-09-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 169675-09-6(Hazardous Substances Data)

169675-09-6 Usage

Uses

Used in Pharmaceutical Industry:
Ro 60-0175 fumarate is used as a pharmacological tool for studying the role and function of 5-HT2 receptors in various physiological and pathological processes. Its high selectivity for 5-HT2A and 5-HT2C receptors makes it a valuable compound for investigating the underlying mechanisms of these receptors in conditions such as schizophrenia, anxiety, and depression.
Used in Research Applications:
In research, Ro 60-0175 fumarate serves as a potent agonist to explore the activation of 5-HT2 receptors, which can help in understanding the receptor's involvement in cellular signaling pathways and potential therapeutic targets for various diseases. Its ability to increase plasma levels of corticosterone, oxytocin, and prolactin in rats makes it a useful compound for studying the neuroendocrine system and the effects of serotonin on hormone regulation.
Used in Drug Development:
Ro 60-0175 fumarate can be utilized in the development of new drugs targeting 5-HT2 receptors, particularly for conditions where the modulation of these receptors is believed to be beneficial. Its selectivity and potency make it a promising starting point for designing more effective and safer medications with fewer side effects.

Biological Activity

Potent, selective 5-HT 2 receptor agonist; shows selectivity for the 5-HT 2C subtype (pK i values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT 2C , 2A , 1A , 6 and 7 receptors respectively). Centrally active following oral or systemic administration in vivo .

Check Digit Verification of cas no

The CAS Registry Mumber 169675-09-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,6,7 and 5 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 169675-09:
(8*1)+(7*6)+(6*9)+(5*6)+(4*7)+(3*5)+(2*0)+(1*9)=186
186 % 10 = 6
So 169675-09-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H12ClFN2.C4H4O4/c1-7(14)6-15-3-2-8-4-10(13)9(12)5-11(8)15;5-3(6)1-2-4(7)8/h2-5,7H,6,14H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t7-;/m0./s1

169675-09-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Ro 60-0175 fumarate,(αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanaminefumarate

1.2 Other means of identification

Product number -
Other names RO 60-0175 FUMARATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:169675-09-6 SDS

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