169679-13-4

Upstream product

• 32779-36-5 5-Bromo-2-chloropyrimidine 
• 169677-40-1 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(4-methylphenyl)-2-n-propylpyrimidin-4-yl]benzenesulfonamide 
• 169677-55-8 4-tert-butyl-N-[6-chloro-5-(4-methylphenyl)-2-n-propylpyrimidin-4-yl]benzenesulfonamide 
• 169677-53-6 5-(4-methylphenyl)-4,6-dihydroxy-2-n-propylpyrimidine 
• 169677-54-7 5-(4-methylphenyl)-4,6-dichloro-2-n-propylpyrimidine 
• 29148-27-4 diethyl 2-(4-methylphenyl)propane-1,3-dioate 
• 6292-59-7 4-tert-butylbenzenesulphonamide 

Relevant academic research and scientific papers

Modifications and structure-activity relationships at the 2-position of 4-sulfonamidopyrimidine derivatives as potent endothelin antagonists

To improve water solubility and to study structure-activity relationships, we modified the structure of the pyrimidine nucleus of each of a series of potent ETA antagonists, 3a and 4a, at the 2-position. In a previous study, each of these antag

Benzenesulfonamide derivative and process for preparing thereof

A benzenesulfonamide derivative of the formula [I]: STR1 wherein Ring A and Ring B are the same or different and each substituted or unsubstituted benzene ring, Q is a single bond or a group of the formula: --O--, --S--, --SO--, --SO2 -- or --CH2--, Y is a group of the formula: --O--, --S-- or --NH--, Alk is lower alkylene group or lower alkenylene group, Z is a single bond or a group of the formula: --O-- or --NH--, R is a substituted or unsubstituted aromatic heterocyclic or aryl group, R1 is hydrogen atom, trifluoromethyl group, substituted or unsubstituted lower alkyl group, substituted or unsubstituted lower alkenyl group, mono-- or di-lower alkylamino group, substituted or unsubstituted lower alkylthio group, substituted or unsubstituted lower alkoxy group, substituted or unsubstituted lower alkynyl group, aromatic heterocyclic group, substituted or unsubstituted aliphatic heterocyclic group or aryl group, provided that when Z is a single bond, R is a substituted or unsubstituted aromatic heterocyclic group, or a pharmaceutically acceptable salt thereof, and processes for preparing the same, these compounds having endothelin antagonistic activity and being useful in the prophylaxis or treatment of various diseases caused by endothelin.