169679-15-6

Basic information

• Product Name: C₃₁H₃₀BrN₇O₆S
• CAS NO: 169679-15-6
• Molecular Weight: 708.592
• Mol File: 169679-15-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₁H₃₀BrN₇O₆S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₃₀BrN₇O₆S(169679-15-6)
• EPA Substance Registry System: C₃₁H₃₀BrN₇O₆S(169679-15-6)

Safety Data

• Hazardous Substances Data: 169679-15-6(Hazardous Substances Data)

Upstream product

• 150728-13-5 4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 
• 32779-36-5 5-Bromo-2-chloropyrimidine 
• 147536-97-8 bosentan 

Relevant articles and documents

The discovery of N -[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy] ethoxy]-4-pyrimidinyl]- N ′-propylsulfamide (macitentan), an orally active, potent dual endothelin receptor antagonist

Starting from the structure of bosentan (1), we embarked on a medicinal chemistry program aiming at the identification of novel potent dual endothelin receptor antagonists with high oral efficacy. This led to the discovery of a novel series of alkyl sulfamide substituted pyrimidines. Among these, compound 17 (macitentan, ACT-064992) emerged as particularly interesting as it is a potent inhibitor of ETA with significant affinity for the ET B receptor and shows excellent pharmacokinetic properties and high in vivo efficacy in hypertensive Dahl salt-sensitive rats. Compound 17 successfully completed a long-term phase III clinical trial for pulmonary arterial hypertension.