169687-97-2

Basic information

• Product Name: N²-(4-Butyl-phenyl)-9-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purine-2,6-diamine
• Synonyms: N²-(4-Butyl-phenyl)-9-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purine-2,6-diamine
• CAS NO: 169687-97-2
• Molecular Weight: 640.974
• Mol File: 169687-97-2.mol

Chemical Properties

• CAS DataBase Reference: N²-(4-Butyl-phenyl)-9-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purine-2,6-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-(4-Butyl-phenyl)-9-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purine-2,6-diamine(169687-97-2)
• EPA Substance Registry System: N²-(4-Butyl-phenyl)-9-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purine-2,6-diamine(169687-97-2)

Safety Data

• Hazardous Substances Data: 169687-97-2(Hazardous Substances Data)

Upstream product

• 94042-04-3 6-amino-2-iodo-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine 
• 87781-97-3 N²-(4-n-butylphenyl)-2',3',5'-O-triacetylguanosine 
• 115952-29-9 2',3',5'-tri-O-acetyl-2-iodoinosine 
• 169687-93-8 Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester 
• 205445-24-5 (2R,3R,3aS,9aR)-2-[6-Amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ol 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 104-13-2 4-Butylaniline 
• 169687-92-7 2-(4-butyl-anilino)-adenosine 
• 169687-94-9 9-((2R,3S,3aR,9aR)-3-Bromo-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-N²-(4-butyl-phenyl)-9H-purine-2,6-diamine 

Downstream Products

• 99304-82-2 2-(p-n-butylanilino)-2'-deoxyadenosine 

Relevant articles and documents

Synthetic nucleosides and nucleotides. 40. Selective inhibition of eukaryotic dna polymerase by 9-(β-D-arabinofuranosyl)-2-(p-n-butylanilino) adenine 5'-triphosphate (BuAaraATP) and its 2'-up azido analog: Synthesis and enzymatic evaluations

Starting from 2',3',5'-tri-O-acetyl-2-iodoadenosine, 9-(β-D- arabinofuranosyl)-2-(p-n-butylanilino)adenine and its 2'(S)-azido counterparts were synthesized in seven steps. These exhibited only moderate growth-inhibitory effects against mouse leukemic P388 cells (IC50 = 13-24 μM), although 5'-triphosphate derivatives showed strong and selective inhibitory action on calf thymus DNA polymerase α, but not on β- and ε- polymerases from eukaryotes.

Synthesis and biological activities of sugar-modified 2-(p-n- butylanilino)-2'-deoxyadenosine analogues

Several sugar-modified 2-(p-n-butylanilino)-2'-deoxyadenosine analogues, including arabino and 2'(R)-azido-2'-deoxy analogues and their 5'- triphosphates were synthesized. These nucleosides thus obtained exhibited moderate cytotoxicity against P-388 leukemic cells in culture (IC50 = 13- 24 μM). In contrast to above results, the 5'-triphosphates have been shown to exert strong and selective inhibitory effects on mammalian DNA polymerase α (Ki=0.02-0.04 μM).