169698-48-0

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 91-00-9 Benzhydrylamine 

Downstream Products

• 98977-69-6 (E)-N-methyl-N-(3-phenyl-2-propenyl)diphenylmethanamine 
• 908252-38-0 ethyl 5-(ethoxycarbonyldiethoxymethyl)-1-(diphenylmethyl)-3-phenyl-4,5-dihydro-1H-pyrrole-2-carboxylate 
• 952409-83-5 (E)-N-diphenylmethyl-3-phenylprop-2-en-1-amine 

Relevant academic research and scientific papers

COMPOUNDS AND RELATED METHODS OF USE

Described herein are compounds of formula (I), related compositions, and their use, for example in the formation of α-amino acids or a precursor thereof such as an α-aminonitrile.

Highly enantioselective titanium-catalyzed cyanation of imines at room temperature

(Figure presented) A highly active and enantioselective titanium-catalyzed cyanatlon of imines at room temperature Is described. The catalyst used Is a partially hydrolyzed titanium alkoxide (PHTA) precatalyst together with a readily available N-salicyl-β-aminoalcohol ligand. Up to 98% ee was obtained with quantitative yields In 15 min of reaction time using 5 mol % of the catalyst. Various N-protecting groups such as benzyl, benzhydryl, Boc, and PMP are tolerated.

Regulation of orthogonal functions in a dual catalyst system. Subservient role of a nonchiral lewis acid in an asymmetric catalytic heteroatom Diels-Alder reaction

A catalytic asymmetric heteroatom Diels-Alder reaction of unactivated imines with Danishefsky's diene is described which gives high asymmetric induction for N-benzhydryl imines derived from a variety of aldehydes. The catalyst is derived from B(OPh)3 and the VAPOL ligand and gives good induction, but the reaction stalls and does not give high conversion (～50%). It was found that in the presence of both the chiral catalyst and excess amounts of B(OPh)3 the reaction proceeds to completion and gives high yields of the dihydropiperidinone product. Despite the presence of large quantities of the nonchiral Lewis acid B(OPh)3, the asymmetric induction of the product remains constant (90% ee) as the amount of B(OPh)3 is steadily increased and does not drop off until the ratio of B(OPh)3 to VAPOL is 100:1 (82% ee). These observations are interpreted as involving highly separated and different activities for the chiral and nonchiral Lewis acids present in the reaction. Specifically, the excess B(OPh)3 serves to bind to the product and release the chiral catalyst to turnover more starting material. The B(OPh)3 does not compete in turning over the starting material, and a series of binding studies reveal that this is likely due to a combination of two factors. The binding studies reveal that the chiral catalyst binds to the starting imine 7 times more strongly than does B(OPh)3. However, in order to explain the constant asymmetric induction observed despite the addition of increasing amounts of B(OPh)3, the rate of the reaction of the imine complexed with the chiral catalyst must be at least 10 times faster than the reaction of the imine complexed with B(OPh)3. Finally, a catalyst generated from BINOL and B(OPh)3 does not show this phenomenon. Copyright

Synthesis and Structure-Activity Relationships of Naftifine-Related Allylamine Antimycotics

Naftifine (1) is the first representative of the new antifungal allylamine derivatives.Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals.A tertiary allylamine function seems to be a prerequisite for activity against fungi.By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations.Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.