169750-88-3

Basic information

• Product Name: 1H-Pyrrolo[2,3-c]pyridine-1-carboxylic acid
• Synonyms: 1H-Pyrrolo[2,3-c]pyridine-1-carboxylic acid;tert-butyl octahydro-1H-pyrrolo[2,3-c]pyridine-1- carboxylate
• CAS NO: 169750-88-3
• Molecular Formula: C₁₂H₂₂N₂O₂
• Molecular Weight: 162
• Mol File: 169750-88-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 313.8±15.0 °C(Predicted)
• Appearance: /
• Density: 1.052±0.06 g/cm3(Predicted)
• PKA: 10.74±0.20(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-c]pyridine-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-c]pyridine-1-carboxylic acid(169750-88-3)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-c]pyridine-1-carboxylic acid(169750-88-3)

Safety Data

• Hazardous Substances Data: 169750-88-3(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[2,3-c]pyridine-1-carboxylic acid, also known as CPP, is a heterocyclic organic compound with the molecular formula C9H6N2O2. It is a derivative of pyrrolopyridine and serves as a building block in the synthesis of pharmaceutical compounds and agrochemicals. CPP is also used as a precursor in the preparation of various bioactive molecules, including potential anticancer and antiviral agents. Its unique structure makes it a versatile intermediate in organic synthesis and medicinal chemistry, with potential applications in drug discovery and development.

Upstream product

• 370880-82-3 tert-butyl 1H-pyrrolo [2,3-c]pyridine-1-carboxylate 
• 271-29-4 6-azaindole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 34619-03-9 tert-butyldicarbonate 

Downstream Products

• 1374243-44-3 tert-butyl 6-(2-(3,5-dichlorophenylamino)acetyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate 
• 1374243-70-5 C₁₅H₁₉Cl₂N₃O 
• 1374239-82-3 2-(3,5-dichlorophenylamino)-1-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-octahydro-1H-pyrrolo[2,3-c]pyridin-6-yl]ethanone 
• 1374239-83-4 1-(1-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)tetrahydro-1H-pyrrolo[2,3-c]pyridine-6(2H,7H,7aH)-yl)-2-(3,5-dichlorophenylamino)ethanone 
• 1374243-45-4 C₂₆H₃₅Cl₂N₇O₂Si 
• 1374240-00-2 1-((3aS,7aS)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)tetrahydro-1H-pyrrolo[2,3-c]pyridine-6(2H,7H,7aH)-yl)-2-(3,5-dichlorophenylamino)ethanone 
• 1374240-01-3 1-((3aR,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)tetrahydro-1H-pyrrolo[2,3-c]pyridine-6(2H,7H,7aH)-yl)-2-(3,5-dichlorophenylamino)ethanone 
• 1438072-83-3 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(1-methylhexahydro-1H-pyrrolo[2,3-c]pyridin-6(2H)-yl)propoxy)quinazolin-4-amine 
• 1438072-77-5 N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-1H-pyrrolo[2,3-c]pyridin-6(2H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438081-00-5 tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[2,3-c] pyridine-1-carboxylate 
• 1350916-85-6 N-[3-fluoro-2-(octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl)phenyl]-4-(2-methyl-4-pyridinyl)-1H-imidazole-2-carboxamide 
• 1350918-43-2 tert-butyl 6-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate 
• 1350918-42-1 tert-butyl 6-(2-amino-6-fluorophenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate 
• 1350918-41-0 tert-butyl 6-(2-fluoro-6-nitrophenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate 

Relevant articles and documents

QUINAZOLINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF

Provided herein are novel compounds, for example, compounds having a Formula (I), Formula (II), or Formula (III), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12D in a cancer cell, and/or in treating various cancer such as pancreatic cancer, colorectal cancer, lung cancer or endometrial cancer.

DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY

The disclosure provides compounds having formula (I), wherein the substituents are as defined herein. The compounds are useful for modulating the dopamine D3 receptor and for treating conditions associated therewith, such as addictions, drug dependency, and psychiatric conditions.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.