169751-10-4

Basic information

• Product Name: Sulfo-N-succinimidyl 6-[3-(2-Pyridyldithio)propionamido] Hexanoate, Sodium Salt
• Synonyms: 2,5-Dioxo-1-[[1-oxo-6-[[1-oxo-3-(2-pyridinyldithio)propyl]amino]hexyl]oxy]-3-pyrrolidinesulfonic Acid Monosodium Salt;2,5-Dioxo-1-[[1-oxo-6-[[1-oxo-3-(2-pyridinyldithio)propyl]aMino]hexyl]oxy]-;SPDP-C6-Sulfo-NHS ester
• CAS NO: 169751-10-4
• Molecular Formula: C18H22N3NaO8S3
• Molecular Weight: 529.57
• Product Categories: Nitric Oxide Reagents;Cross Linking Reagents;Heterocycles;MTS & Sulfhydryl Active Reagents;Sulfur & Selenium Compounds;heteroXlink
• Mol File: 169751-10-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 185-187°C
• Appearance: /
• Density: 1.53g/cm³
• Refractive Index: 1.64
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly)
• Stability: Moisture Sensitive
• CAS DataBase Reference: Sulfo-N-succinimidyl 6-[3-(2-Pyridyldithio)propionamido] Hexanoate, Sodium Salt(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfo-N-succinimidyl 6-[3-(2-Pyridyldithio)propionamido] Hexanoate, Sodium Salt(169751-10-4)
• EPA Substance Registry System: Sulfo-N-succinimidyl 6-[3-(2-Pyridyldithio)propionamido] Hexanoate, Sodium Salt(169751-10-4)

Safety Data

• Hazardous Substances Data: 169751-10-4(Hazardous Substances Data)

Usage

Description

Sulfo-N-succinimidyl 6-[3-(2-Pyridyldithio)propionamido] Hexanoate, Sodium Salt, also known as SPDP-C6-Sulfo-NHS ester, is a water-soluble crosslinker containing a cleavable disulfide bond. It is reactive towards amine and sulfhydryl groups and can be utilized for bioconjugation. SPDP-C6-Sulfo-NHS ester has a spacer arm of 15.6 angstroms and is presented as an off-white solid.

Uses

1. Used in Bioconjugation Applications:
Sulfo-N-succinimidyl 6-[3-(2-Pyridyldithio)propionamido] Hexanoate, Sodium Salt is used as a heterobifunctional protein crosslinking reagent for bioconjugation purposes. It facilitates the covalent attachment of proteins, peptides, or other biomolecules to each other or to various surfaces, enabling the creation of stable and functional bioconjugates.
2. Used in Pharmaceutical Industry:
In the pharmaceutical industry, Sulfo-N-succinimidyl 6-[3-(2-Pyridyldithio)propionamido] Hexanoate, Sodium Salt is used as a key component in the development of drug delivery systems. Its ability to form stable covalent bonds with amine and sulfhydryl groups allows for the targeted delivery of therapeutic agents, improving their bioavailability and efficacy.
3. Used in Research and Development:
Sulfo-N-succinimidyl 6-[3-(2-Pyridyldithio)propionamido] Hexanoate, Sodium Salt is employed in research and development for the creation of novel bioconjugates and the study of protein-protein interactions. Its reactivity with amine and sulfhydryl groups makes it a valuable tool for exploring the structure and function of various biomolecules.
4. Used in Diagnostic Applications:
In the field of diagnostics, Sulfo-N-succinimidyl 6-[3-(2-Pyridyldithio)propionamido] Hexanoate, Sodium Salt is used for the development of immunoassays and other diagnostic tools. Its ability to form stable bioconjugates allows for the creation of highly sensitive and specific diagnostic reagents, aiding in the early detection and monitoring of various diseases and conditions.

InChI:InChI=1/C18H23N3O8S3/c22-14(8-11-30-31-15-6-3-5-10-20-15)19-9-4-1-2-7-17(24)29-21-16(23)12-13(18(21)25)32(26,27)28/h3,5-6,10,13H,1-2,4,7-9,11-12H2,(H,19,22)(H,26,27,28)