169774-76-9

Basic information

• Product Name: (2S,3S)-N-benzoyl-2-methoxycarbonyl-3-methoxycarbonylmethyl-4-(2-methoxyphenyl)-<4,5>-dehydropyrrolidine
• Synonyms: (2S,3S)-N-benzoyl-2-methoxycarbonyl-3-methoxycarbonylmethyl-4-(2-methoxyphenyl)-<4,5>-dehydropyrrolidine
• CAS NO: 169774-76-9
• Molecular Weight: 409.439
• Mol File: 169774-76-9.mol

Chemical Properties

• CAS DataBase Reference: (2S,3S)-N-benzoyl-2-methoxycarbonyl-3-methoxycarbonylmethyl-4-(2-methoxyphenyl)-<4,5>-dehydropyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-N-benzoyl-2-methoxycarbonyl-3-methoxycarbonylmethyl-4-(2-methoxyphenyl)-<4,5>-dehydropyrrolidine(169774-76-9)
• EPA Substance Registry System: (2S,3S)-N-benzoyl-2-methoxycarbonyl-3-methoxycarbonylmethyl-4-(2-methoxyphenyl)-<4,5>-dehydropyrrolidine(169774-76-9)

Safety Data

• Hazardous Substances Data: 169774-76-9(Hazardous Substances Data)

Upstream product

• 169774-67-8 (2S,3S)-N-benzoyl-2-methoxycarbonyl-3-tert-butoxycarbonylmethyl-4-(2-methoxyphenyl)-<4,5>-dehydropyrrolidine 
• 186581-53-3 diazomethane 
• 189573-92-0 (2S,3S)-1-Benzoyl-3-carboxymethyl-4-(2-methoxy-phenyl)-2,3-dihydro-1H-pyrrole-2-carboxylic acid methyl ester 

Downstream Products

• 132785-33-2 MFPA 
• 169774-84-9 (2S,3S,4R)-N-benzoyl-2-methoxycarbonyl-3-methoxycarbonylmethyl-4-(2-methoxyphenyl)pyrrolidine 
• 169774-80-5 (2S,3S,4S)-N-benzoyl-2-methoxycarbonyl-3-methoxycarbonylmethyl-4-(2-methoxyphenyl)pyrrolidine 

Relevant articles and documents

Towards a versatile synthesis of kainoids II: Two methods for establishment of C-4 stereochemistry

Benzylic lactone hydrogenolysis and enamide reduction were used to generate protected C-4 aryl substituted kainoid analogues which were deprotected to their corresponding free amino acids. X-ray crystographic data were obtained for the C-4 2-MeOPh- analogue.

A versatile approach to acromelic acid analogues

A route to acromelic acid analogues and their corresponding C-4 epimers from trans-4-hydroxy-L-proline is described. The C-4 substituent was introduced by a Suzuki-type boronate coupling to a vinyl triflate.