169774-81-6

Basic information

• Product Name: 3-Pyrrolidineacetic acid, 1-benzoyl-2-(methoxycarbonyl)-4-(3-methoxyphenyl)-, methyl ester, (2S,3S,4S)-
• CAS NO: 169774-81-6
• Molecular Formula: C23H25NO6
• Molecular Weight: 411.455
• Mol File: 169774-81-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Pyrrolidineacetic acid, 1-benzoyl-2-(methoxycarbonyl)-4-(3-methoxyphenyl)-, methyl ester, (2S,3S,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyrrolidineacetic acid, 1-benzoyl-2-(methoxycarbonyl)-4-(3-methoxyphenyl)-, methyl ester, (2S,3S,4S)-(169774-81-6)
• EPA Substance Registry System: 3-Pyrrolidineacetic acid, 1-benzoyl-2-(methoxycarbonyl)-4-(3-methoxyphenyl)-, methyl ester, (2S,3S,4S)-(169774-81-6)

Safety Data

• Hazardous Substances Data: 169774-81-6(Hazardous Substances Data)

Upstream product

• 189573-94-2 (2S,3S)-1-Benzoyl-3-carboxymethyl-4-(3-methoxy-phenyl)-2,3-dihydro-1H-pyrrole-2-carboxylic acid methyl ester 
• 169774-69-0 (2S,3S)-N-benzoyl-2-methoxycarbonyl-3-tert-butoxycarbonylmethyl-4-(3-methoxyphenyl)-<4,5>-dehydropyrrolidine 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 169774-77-0 (2S,3S)-N-benzoyl-2-methoxycarbonyl-3-methoxycarbonylmethyl-4-(3-methoxyphenyl)-<4,5>-dehydropyrrolidine 

Relevant articles and documents

Towards a versatile synthesis of kainoids II: Two methods for establishment of C-4 stereochemistry

Benzylic lactone hydrogenolysis and enamide reduction were used to generate protected C-4 aryl substituted kainoid analogues which were deprotected to their corresponding free amino acids. X-ray crystographic data were obtained for the C-4 2-MeOPh- analogue.

A versatile approach to acromelic acid analogues

A route to acromelic acid analogues and their corresponding C-4 epimers from trans-4-hydroxy-L-proline is described. The C-4 substituent was introduced by a Suzuki-type boronate coupling to a vinyl triflate.