169789-47-3 Usage
General Description
5-ETHOXY-1H-INDOLE-3-CARBALDEHYDE is a chemical compound that belongs to the class of indole carbaldehydes. It is a derivative of indole, which is a heterocyclic aromatic organic compound. 5-ETHOXY-1H-INDOLE-3-CARBALDEHYDE is characterized by the presence of an ethoxy group and a carbonyl group attached to the indole ring. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and biologically active molecules. Additionally, it exhibits interesting pharmacological properties and is being studied for its potential applications in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 169789-47-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,7,8 and 9 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 169789-47:
(8*1)+(7*6)+(6*9)+(5*7)+(4*8)+(3*9)+(2*4)+(1*7)=213
213 % 10 = 3
So 169789-47-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H11NO2/c1-2-14-9-3-4-11-10(5-9)8(7-13)6-12-11/h3-7,12H,2H2,1H3
169789-47-3Relevant articles and documents
The serotonin 5-HT4 receptor. 2. Structure-activity studies of the indole carbazimidamide class of agonists.
Buchheit,Gamse,Giger,Hoyer,Klein,Kloeppner,Pfannkuche,Mattes
, p. 2331 - 2338 (2007/10/02)
A number of substituted indole carbazimidamides were prepared and evaluated as 5-HT4 receptor agonists by using the isolated field-stimulated guinea pig ileum preparation. Their selectivity for the 5-HT4 receptor was established by examining their affinity for other 5-HT receptors using radioligand-binding techniques. Several selective and highly potent full as well as partial agonists emerged from this study. For example, 1b,d were found to be the most potent, full 5-HT4 receptor agonist described so far (EC50 = 0.5 and 0.8 nM, respectively), being 6 and 4 times more potent than serotonin itself. On the other hand, 5b and 1h appeared as partial 5-HT4 receptor agonists in the nonstimulated guinea pig ileum preparation with potencies, evaluated against serotonin action, respectively similar (5b, Ki = 12 nM) to and 300-fold higher (1h, Ki = 0.04 nM) than serotonin.
