169884-67-7

Basic information

• Product Name: Cis-2-fluorocyclopropyl)methanol
• Synonyms: Cis-2-fluorocyclopropyl)methanol
• CAS NO: 169884-67-7
• Molecular Formula: C4H7FO
• Molecular Weight: 90.1
• Mol File: 169884-67-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Cis-2-fluorocyclopropyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: Cis-2-fluorocyclopropyl)methanol(169884-67-7)
• EPA Substance Registry System: Cis-2-fluorocyclopropyl)methanol(169884-67-7)

Safety Data

• Hazardous Substances Data: 169884-67-7(Hazardous Substances Data)

Usage

General Description

Cis-2-fluorocyclopropyl)methanol is a chemical compound with the molecular formula C4H7FO. It is a fluorinated cyclopropyl alcohol with a cis configuration, meaning the fluorine and hydroxyl groups are on the same side of the cyclopropyl ring. Cis-2-fluorocyclopropyl)methanol is of interest in medicinal chemistry and drug development due to the unique three-membered cyclopropyl ring and the fluorine substitution, which can impart specific properties to the molecule. Additionally, the presence of a hydroxyl group makes cis-2-fluorocyclopropyl)methanol a potential building block for the synthesis of more complex organic compounds. Its chemical and structural characteristics make it a valuable tool for understanding the reactivity and biological activity of similar compounds.

Upstream product

• 105919-34-4 (+/-)-trans-2-fluorocyclopropanecarboxylic acid 
• 167073-07-6 (±)-cis-2-fluorocyclopropanecarboxylic acid 
• 127199-13-7 (1R,2R)-(-)-cis-2-fluoro-cyclopropanecarboxylic acid 
• 167073-07-6 (1R,2S)-2-fluorocyclopropanecarboxylic acid 
• 188428-48-0 (1R,2S)-ethyl 2-fluorocyclopropanecarboxylate 

Relevant articles and documents

Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups

A systematic comparison of lipophilicity modulations upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl substituents, at a single carbon atom, is provided using directly comparable, and easily accessible model compounds. In addition, comparison with relevant linear chain derivatives is provided, as well as lipophilicity changes occurring upon chain extension of acyclic precursors to give cyclopropyl containing compounds. For the compounds investigated, fluorination of the isopropyl substituent led to larger lipophilicity modulation compared to fluorination of the cyclopropyl substituent.

4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS

The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.