169887-39-2Relevant academic research and scientific papers
Palladium-Catalyzed Aminocarbonylation in Solid-Phase Peptide Synthesis: A Method for Capping, Cyclization, and Isotope Labeling
Skogh, Anna,Friis, Stig D.,Skrydstrup, Troels,Sandstr?m, Anja
supporting information, p. 2873 - 2876 (2017/06/07)
A new synthetic approach for introducing N-capping groups onto peptides attached to a solid support, combining aminocarbonylation under mild conditions using a palladacycle precatalyst and solid-phase peptide synthesis, is reported. The use of a silacarboxylic acid as an in situ CO-releasing molecule allowed the reaction to be performed in a single vial. The method also enables versatile substitution of side chains, side-chain-to-side-chain cyclizations, and selective [13C] acyl labeling of modified peptides.
Allylboration of α-Amino Ketones
Pace, R. David,Kabalka, George W.
, p. 4838 - 4844 (2007/10/02)
A series of unsaturated α-amino alcohols were prepared via the allylboration of the corresponding N-protected α-amino ketones.The reactions are stereoselective, producing the syn isomers.The diastereoselectivity is not dramatically affected by the electro
