1698878-14-6 Usage
Description
Nampt-IN-1 is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt; IC50 = 3.1 nM). It is selective for Nampt over a panel of greater than 100 human kinases at 1 μM. Nampt-IN-1 inhibits NAD+ formation in and proliferation of HCT116 cells (IC50s = 1.8 and 8.9 nM, respectively). It inhibits cell growth in a panel of cancer cell lines (IC50s = <0.2-2 μM). Nampt-IN-1 inhibits NAD+ formation in an A2780 ovarian carcinoma mouse xenograft model (ED50 = 2 mg/kg).
Uses
Nampt-IN-1 functions as a co-drug. Nampt-IN-1 is a potent and selective NAMPT inhibitor.
Biochem/physiol Actions
LSN3154567 might be useful in developing a novel cancer therapeutic.
Check Digit Verification of cas no
The CAS Registry Mumber 1698878-14-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,9,8,8,7 and 8 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1698878-14:
(9*1)+(8*6)+(7*9)+(6*8)+(5*8)+(4*7)+(3*8)+(2*1)+(1*4)=266
266 % 10 = 6
So 1698878-14-6 is a valid CAS Registry Number.
1698878-14-6Relevant articles and documents
NOVEL PYRIDYLOXYACETYL TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS NAMPT INHIBITORS
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Page/Page column 29; 30, (2015/04/28)
The present invention provides novel pyridyloxyacetyl tetrahydroisoquinoline compounds that inhibit NAMPT and may be useful in the treatment of cancer.