169888-83-9Relevant academic research and scientific papers
On the optimization of pig pancreatic lipase catalyzed monoacetylation of prochiral diols
Banfi,Guanti,Riva
, p. 1345 - 1356 (1995)
The effect of various experimental variables (solvent, methodology of supportation on celite, presence of water, conversion and so on) on the rate and on the enantioselectivity of monoacetylation of some prochiral 2-substituted-1,3-propanediols with vinyl acetate catalyzed by crude PPL (pig pancreatic lipase) was analyzed. This study allowed to assess the best conditions for performing these transformations, providing an efficient methodology for the synthesis of valuable chiral building blocks with moderate amounts of inexpensive PPL, which can also be easily recycled.
Chemoenzymatic approach to the AB ring system of Aklavinone
Guanti, Giuseppe,Banfi, Luca,Brusco, Stefano,Riva, Renata
, p. 8549 - 8552 (2007/10/02)
Both enantiomers of compound 3, a possible intermediate for the AB ring system 2 of Aklavinone 1, were obtained in optically active form from diol 7. Key steps were the preparation of both enantiomers of monoacetate 8d, via enzymatic reactions that utiliz
