169898-24-2Relevant articles and documents
Ring A building blocks for taxoids and taxamycins
Tjepkema, Michael W.,Wilson, Peter D.,Audrain, Helene,Fallis, Alex G.
, p. 1215 - 1224 (2007/10/03)
The synthesis of a series of oxygenated cyclohexene ring A synthons 20, 22-27, 34, 36, and 37 that possess suitable functionality for further elaboration for taxoid synthesis are described. These compounds have been prepared from β-ionone by a series of oxidative and addition reactions or alternatively by Lewis acid catalyzed Diels-Alder cycloadditions with the oxygen-containing trimethyl substituted dienes 31 and 33. The syntheses of a series of oxygenated cyclohexene ring A synthons 20, 22-27, 34, 36, and 37 that possess suitable functionality for further elaboration for taxoid synthesis are described. These compounds have been prepared from β-ionone by a series of oxidative and addition reactions or alternatively by Lewis acid catalyzed Diels-Alder cycloadditions with the oxygen-containing trimethyl substituted dienes 31 and 33.
Synthesis of Functionalized Ring A Building Blocks for Taxoids
Tjepkema, Michael W.,Wilson, Peter D.,Wong, Timothy,Romero, Miguel A.,Audrain, Helene,Fallis, Alex G.
, p. 6039 - 6042 (2007/10/02)
The synthesis of a series of oxygenated cyclohexenes 1, 2, 11, 14, 18, and 19 that possess suitable functionality for further elaboration for taxoid synthesis is described.These compounds have been prepared from β-ionone by a series of oxidative and addition reactions or alternatively by a Lewis acid catalyzed intermolecular Diels-Alder reaction in which the A-ring is constructed directly.
