169899-49-4 Usage
General Description
Cyclobutanecarboxylic acid, 3-hydroxy-1-methyl-, methyl ester (9CI) is a chemical compound with the molecular formula C8H14O3. It is also known as 1-Methyl-3-hydroxycyclobutane-1-carboxylic acid methyl ester. Cyclobutanecarboxylic acid, 3-hydroxy-1-methyl-, methyl ester (9CI) is a colorless liquid with a faint odor, and it is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also used as a flavoring agent in the food industry. The compound is considered to have low toxicity, but it should be handled with care as it may cause irritation to the eyes, skin, and respiratory system upon direct exposure. Overall, Cyclobutanecarboxylic acid, 3-hydroxy-1-methyl-, methyl ester (9CI) has various industrial applications and is an important intermediate in the production of pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 169899-49-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,8,9 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 169899-49:
(8*1)+(7*6)+(6*9)+(5*8)+(4*9)+(3*9)+(2*4)+(1*9)=224
224 % 10 = 4
So 169899-49-4 is a valid CAS Registry Number.
169899-49-4Relevant articles and documents
Synthesis of Electron-Deficient Heteroaromatic 1,3-Substituted Cyclobutyls via Zinc Insertion/Negishi Coupling Sequence under Batch and Automated Flow Conditions
Tissot, Matthieu,Body, Nathalie,Petit, Sylvain,Claessens, Jehan,Genicot, Christophe,Pasau, Patrick
supporting information, p. 8022 - 8025 (2019/01/04)
Synthesis of 1,3-substituted cyclobutyls enabled by zinc insertion into functionalized iodocyclobutyl derivatives followed by Negishi coupling with halo-heteroaromatics is reported. Two distinct sets of conditions were developed; the first involved a two-step batch protocol using activated Rieke zinc, and the second involved a multistep continuous flow process. Both methods showed complementarity and allowed for rapid access to these medicinally relevant motifs, the possibility of scaling up, and automation for library synthesis.
THE TORQUOSELECTIVITY OF ELECTROCYCLIC REACTIONS OF 3-DONOR-3-ACCEPTOR-SUBSTITUTED CYCLOBUTENES
Niwayama, Satomi,Wang, Ying,Houk, K. N.
, p. 6201 - 6204 (2007/10/02)
Theory predicts that electron donors have larger outward rotation preferences than acceptors in thermal ring opening of cyclobutenes.Experimental verifications are presented for several 3,3-disubstituted cyclobutenes.
