169899-79-0Relevant academic research and scientific papers
Synthetic studies on bryostatins, potent antineoplastic agents: Synthesis of the C17-C27 fragment of C20 oxygenated bryostatins
Ohmori,Nishiyama,Yamamura
, p. 6519 - 6522 (1995)
Synthetic process towards the bottom half portion of C20 oxygenated series of bryostatins is described. The stereogenic center at C20 position was constructed through a hydroxyl group-directed epoxidation by using mCPBA. It was found that silver (I) salt is an effective and mild reagent for regioselective ring cleavage of α-bromoepoxides into the corresponding α-hydroxyketones via oxonium ion intermediates.
