16990-60-6

Basic information

• Product Name: NPS-SER(TBU)-OH DCHA
• Synonyms: 2-NITROPHENYLSULFANYL-O-T-BUTYL-L-SERINE DICYCLOHEXYLAMMONIUM SALT;NPS-SERINE(TBU)-OH DCHA;NPS-SER(TBU)-OH DCHA;N-O-NPS-O-T-BUTYL-L-SER DHCA SALT;N-ALPHA-(2-NITROPHENYLSULFANYL)-O-T-BUTYL-L-SERINE DICYCLOHEXYLAMMONIUM SALT;(S)-2-(2-NITROPHENYLSULFANYL)AMINO-3-T-BUTOXYPROPIONIC ACID DICYCLOHEXYLAMMONIUM SALT;O-tert-butyl-N-[(2-nitrophenyl)thio]-L-serine, compound with dicyclohexylamine (1:1);Nps-Ser(tBu)-OH
• CAS NO: 16990-60-6
• Molecular Formula: C₁₂H₂₃N*C₁₃H₁₈N₂O₅S
• Molecular Weight: 495.68
• EINECS: 241-068-3
• Mol File: 16990-60-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 635.5°Cat760mmHg
• Flash Point: 338.1°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 5.06E-17mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: NPS-SER(TBU)-OH DCHA(CAS DataBase Reference)
• NIST Chemistry Reference: NPS-SER(TBU)-OH DCHA(16990-60-6)
• EPA Substance Registry System: NPS-SER(TBU)-OH DCHA(16990-60-6)

Safety Data

• Hazardous Substances Data: 16990-60-6(Hazardous Substances Data)

Usage

General Description

NPS-SER(TBU)-OH also known as N-((tert-butoxycarbonyl)amino)succinimidyl ester (DCHA) is a chemical compound used as a crosslinker in bioconjugation and protein modification. It is a derivative of serine with a tert-butoxycarbonyl (TBU) protecting group, which increases its stability and resistance to hydrolysis. As a succinimidyl ester, NPS-SER(TBU)-OH DCHA reacts with primary amines on proteins and other biomolecules to form stable amide bonds, making it a valuable tool for protein labeling and immobilization in biological research and diagnostics. Its reactive and stable nature makes it ideal for applications such as antibody labeling, protein-protein crosslinking, and the construction of protein arrays.

InChI:InChI=1/C13H18N2O5S.C12H23N/c1-13(2,3)20-8-9(12(16)17)14-21-11-7-5-4-6-10(11)15(18)19;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h4-7,9,14H,8H2,1-3H3,(H,16,17);11-13H,1-10H2/t9-;/m0./s1

Downstream Products

• 75189-52-5 N-o-nitrobenzenesulphenyl-O-tert-butylseryl-O-tert-butylthreonine methyl ester