169945-28-2Relevant academic research and scientific papers
Synthesis and in vitro antiproliferative evaluation of novel hybrids from 1,3,4-Thiadiazole and benzisoselenazolone
Jing, Fen,Fu, Xiaoyun,Li, Sha,Li, Baolin,Zhao, Jijun,Wang, Xuefeng,Liu, Yuming,Chen, Baoquan
, p. 431 - 437 (2015)
Novel hybrids from 1,3,4-thiadiazole and benzisoselenazolone were designed, synthesized and evaluated for their in vitro antiproliferative activities by CCK-8 assay against three types of human cancer cell lines, SMMC-7721, MCF-7 and A549 cells. The preli
Substituted cyclic amine compound, production process thereof and pharmaceutical composition for circulatory organ use containing the same
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, (2008/06/13)
A substituted cyclic amine compound represented by the following general formula (1) STR1 wherein each of R1 to R5 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or the like, A represents a carbonyl group or a sulfonyl group, B represents a methine moiety or a nitrogen atom, D represents a methine moiety, a nitrogen atom or =N(→O)-- and n is an integer of 2 to 3; and synthetic methods thereof. The inventive compound is useful in preventing and treating circulatory organ-related diseases such as hypertension, ischemic heart disease, cerebrovascular disease, peripheral circulatory disease and the like.
