170006-73-2 Usage
Uses
Farnesyltransferase inhibitor 277 (FTI-277) has been used to:inhibit protein farnesylation in breast cell lines.in marrow-isolated adult multilineage inducible cells (MIAMI).inhibition of farnesyl transferase in CV-1 in Origin with SV40 genes cells (COS-7).
Biochem/physiol Actions
Farnesyltransferase inhibitor 277 (FTI-277) mediates apoptosis in multiple myeloma and is regarded as a potential therapeutic agent.
Check Digit Verification of cas no
The CAS Registry Mumber 170006-73-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,0,0 and 6 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 170006-73:
(8*1)+(7*7)+(6*0)+(5*0)+(4*0)+(3*6)+(2*7)+(1*3)=92
92 % 10 = 2
So 170006-73-2 is a valid CAS Registry Number.
170006-73-2Relevant articles and documents
Inhibitors of farnesyltransferase
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, (2008/06/13)
Peptidomimetics of the formula CβX where C is cysteine, X is any naturally occuring amino acid, and β is a hydrophobic spacer, most notably 2-phenyl-4-aminobenzoic acid. These compounds are effective inhibitors of p2lras farnesyltrasferase, block Ras-dependent oncogenic signalling and inhibit human tumor growth in vivo in animal models. Pro-drugs made by functionalizing terminal amino and carboxylic acid groups of peptides and peptidomimetics are also disclosed. Such functionalized derivatives demonstrate increased cell uptake. Other structural modifications are also disclosed.
