170011-16-2Relevant academic research and scientific papers
Oxazolidinone derivatives
-
, (2008/06/13)
The present invention relates to compounds of the formula: STR1 wherein R is H or alkyl; Y1 is --CH= or --N=; and Y2 --CH=, --C(OH)=, --C(NO2)=, --C(NH2)=, --C(Hal)=, --N=; X is cycloalkenyl; bicyclo[2.2.1]hept-2-yl, optionally substituted by phenyl-2-oxo-5 -methoxymethyl-oxazolidinyl; bicyclo[2.2.1]-hept-5 -en-2-yl; adamantyl; or cycloalkyl or piperidinyl, optionally substituted by amino, alkyl, --CN, oxo hydroxyimino, ethylenedioxy or by --OR1, R1 is --CH(C6 H5)2, --(CH2)n C6 H5, alkyl, H, --(CH2)n NHCOCH3, --(CH2)n NH2, --(CH2)n CN, --(CH2)n SCH3 --(CH2)n SO2 CH3, --CO-lower-alkyl, --COC6 H5, optionally substituted by oxazolidine; or by =CR2 R3, R2 is alkyl R3 is H, --CN, alkyl, phenyl or COO-alkyl; or by --(CH2)n R4 R4 is --CN, amino, --NHCOCH3, --COC6 H5 Hal, phenyl or hydroxy; or by --COR5, R5 is alkyl, --CH=CH--C6 H5, --C6 H5, --C6 H5 CF3 or --O-alkyl; or by --NR6 R7, R6 is or --COCH3 ; R7 is --COCH3, benzyl or --(CH2)n NHCOC6 H4 Hal; and n is 1-3; These can be used for the prevention or control of depressive, panic and anxiety states, and treatment of certain cognitive disorders and neurodegenerative diseases.
