170011-57-1

Basic information

• Product Name: 4-P-AMINOPHENYL-1-BOC-PIPERIDINE
• Synonyms: 4-P-AMINOPHENYL-1-BOC-PIPERIDINE ;1-N-Boc-(4-aminophenyl)piperidine;4-(4-Aminophenyl)piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylicacid,4-(4-aMinophenyl)-,1,1-diMethylethylester;tert-Butyl 4-(4-aminophenyl)-1-piperidinecarboxylate;4-(1-Boc-piperidin-4-yl)-phenylamine, 98%
• CAS NO: 170011-57-1
• Molecular Formula: C₁₆H₂₄N₂O₂
• Molecular Weight: 276.37396
• Mol File: 170011-57-1.mol
• Article Data: 29

Chemical Properties

• Melting Point: 119 °C
• Boiling Point: 412.737 °C at 760 mmHg
• Flash Point: 203.417 °C
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.97±0.10(Predicted)
• CAS DataBase Reference: 4-P-AMINOPHENYL-1-BOC-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-P-AMINOPHENYL-1-BOC-PIPERIDINE(170011-57-1)
• EPA Substance Registry System: 4-P-AMINOPHENYL-1-BOC-PIPERIDINE(170011-57-1)

Safety Data

• Hazardous Substances Data: 170011-57-1(Hazardous Substances Data)

Usage

General Description

4-P-Aminophenyl-1-BOC-piperidine is a chemical compound generally used in the field of organic chemistry. It belongs to the class of compounds known as amines, specifically a secondary amine and a tertiary amine. One pivotal characteristic of this chemical is that it has a BOC (tert-butyloxycarbonyl) group which is a common protecting group used in organic synthesis. 4-P-AMINOPHENYL-1-BOC-PIPERIDINE is used in pharmaceuticals and drug synthesis process because it can participate in a wide range of reactions and also acts as a blocker for certain functional groups. The exact properties such as molecular weight, melting point, solubility, and acidity or basicity can be determined via different experimental methods.

InChI:InChI=1/C16H24N2O2/c1-16(2,3)20-15(19)18-10-8-13(9-11-18)12-4-6-14(17)7-5-12/h4-7,13H,8-11,17H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 170011-56-0 4-(4-nitrophenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 873454-43-4 4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 873454-39-8 4-(4-benzyloxycarbonylaminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 4282-45-5 4-(4-nitrophenyl)pyridine 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 387827-33-0 tert-butyl 4-(4-nitrophenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 65145-14-4 N,N-dibenzyl-4-bromoaniline 
• 1428760-73-9 C₃₀H₃₆N₂O₃ 
• 1428760-70-6 C₃₀H₃₄N₂O₂ 
• 586-78-7 para-nitrophenyl bromide 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 

Downstream Products

• 1009083-71-9 tert-butyl 4-(4-(3-(2-(1-(2-chlorophenyl)-3-methyl-1H-pyrazol-5-yloxy)phenyl)ureido)phenyl)piperidine-1-carboxylate 
• 885693-01-6 4-(4-amino-3-cyclohex-1-enyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 885693-02-7 (4-{[4-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carbon-yl]-amino}-3-cyclohex-1-enyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 885692-95-5 4-cyano-1H-imidazole-2-carboxylic acid {2-cyclohex-1-enyl-4-[1-(2,2-dimethyl[1,3]dioxan-5-yl)piperidin-4-yl]phenyl}amide 
• 885693-15-2 4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-ylphenyl)amide trifluoroacetic acid salt 
• 885692-52-4 JNJ-28312141 
• 885693-41-4 4-cyano-1H-imidazole-2-carboxylic acid {2-cyclohex-1-enyl-4-[1-(R)-(+)-(2,2-dimethyl[1,3]dioxolane-4-carbonyl)piperidin-4-yl]phenyl}amide 
• 885692-72-8 4-cyano-1H-imidazole-2-carboxylic acid {2-cyclohex-1-enyl-4-[1-(R)-(+)-(2,3-dihydroxypropionyl)piperidin-4-yl]phenyl}amide 
• 885693-17-4 [2-(4-{4-[(4-cyano-1H-imidazole-2-carbonyl)amino]-3-cyclohex-1-enylphenyl}piperidin-1-yl)-2-oxoethyl]carbamic acid tert-butyl ester 

Relevant articles and documents

WEE1 inhibitors as well as preparation and application thereof

The invention relates to WEE1 inhibitors as well as preparation and application thereof. The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates, polymorphs or isomers thereof, and their use in the preparation of medicaments for the treatment of diseases associated with WEE1 activity.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

PHARMACEUTICAL COMPOUND

Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the general formula (I) detailed within.