170019-09-7

Basic information

• Product Name: 3,3-bis-(3-fluoro-phenyl)-propionitrile
• Synonyms: 3,3-bis-(3-fluoro-phenyl)-propionitrile
• CAS NO: 170019-09-7
• Molecular Weight: 243.256
• Mol File: 170019-09-7.mol

Chemical Properties

• CAS DataBase Reference: 3,3-bis-(3-fluoro-phenyl)-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-bis-(3-fluoro-phenyl)-propionitrile(170019-09-7)
• EPA Substance Registry System: 3,3-bis-(3-fluoro-phenyl)-propionitrile(170019-09-7)

Safety Data

• Hazardous Substances Data: 170019-09-7(Hazardous Substances Data)

Upstream product

• 170019-08-6 3,3'-bis(3-fluorophenyl)acrylonitrile 
• 345-70-0 3,3'-difluorobenzophenone 

Downstream Products

• 170019-11-1 3,3-bis-(3-fluoro-phenyl)-2-methyl-propionitrile 
• 316373-58-7 3,3-bis(3-fluorophenyl)propionaldehyde 
• 316373-59-8 [3,3-Bis-(3-fluoro-phenyl)-prop-(E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 
• 316373-60-1 [(R)-3,3-Bis-(3-fluoro-phenyl)-1-methyl-propyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 
• 170019-13-3 (S)-3,3-Bis-(3-fluoro-phenyl)-2-methyl-propionitrile 
• 170019-12-2 (R)-3,3-Bis-(3-fluoro-phenyl)-2-methyl-propionitrile 

Relevant articles and documents

Chiral synthesis and pharmacological evaluation of NPS 1407: A potent, stereoselective NMDA receptor antagonist

The stereoselective synthesis and biological activity of NPS 1407 (4a), (S)-(-)-3-amino-1,1-bis(3-fluorophenyl)butane, a potent, stereoselective antagonist of the NMDA receptor, are described. The racemate (4) was found to be active at the NMDA receptor in an in vitro assay, prompting the synthesis of the individual stereoisomers. The S isomer (4a) was found to be 12 times more potent than the R isomer (4b). Compound 4a demonstrated in vivo pharmacological activity in neuroprotection and anti-convulsant assays. (C) 2000 Elsevier Science Ltd.

Synthesis, biological activity, and absolute stereochemical assignment of NPS 1392: A potent and stereoselective NMDA receptor antagonist

The synthesis, biological activity, and single crystal X-ray structure of NPS 1392, (R)-(-)-3,3-bis(3-fluorophenyl)-2-methylpropan-1-amine (3a), a potent, stereoselective antagonist of the NMDA receptor, are described. The NMDA receptor selectively bound