170031-73-9Relevant academic research and scientific papers
Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives
Demirayak, eref,Yurtta, Leyla
, p. 811 - 822 (2015/02/19)
The synthesis of some new pyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities were aimed in this work. Thus, 2-acetylbenzimidazole was reacted with appropriate α-bromoacetophenones and potassium carbonate in acetone t
Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3
Hayes, Martin E.,Wallace, Grier A.,Grongsaard, Pintipa,Bischoff, Agnieszka,George, Dawn M.,Miao, Wenyan,McPherson, Michael J.,Stoffel, Robert H.,Green, David W.,Roth, Gregory P.
, p. 1573 - 1576 (2008/09/21)
High-throughput screening identified a low molecular weight antagonist of CXCR3 displaying micromolar activity in a membrane filtration-binding assay. Systematic modification of the benzimidazole core and tethered acetophenone moiety established tractable SAR of analogs with improved physicochemical properties and sub-micromolar activity across both human and murine receptors.
Synthesis and anticancer and anti-HIV testing of some pyrazino[1,2-a]benzimidazole derivatives
Demirayak, Seref,Abu Mohsen, Usama,Cagri Karaburun, Ahmet
, p. 255 - 260 (2007/10/03)
In this study, some 1-methylene-2,3-diaryl-1,2-dihydropyrazino[1,2-a]benzimidazole and some 1-(2-arylvinyl)-3-arylpyrazino[1,2-a]benzimidazole derivatives were synthesised. The structure elucidation of the compounds was performed by IR, 1H-NMR and MASS spectroscopic data and elemental analyses results. Anticancer and anti-HIV activities of the compounds were examined, however no anti-HIV activity was seen; highly notable anticancer activity was obtained. It was also observed that the compounds were more potent against leukaemia cell lines.
Synthesis of some pyrido- and pyrazino-benzimidazole derivatives and their antifungal activity
Demirayak,Guven
, p. 527 - 529 (2007/10/02)
Some 2-aryl-4-hydroxypyrido[1,2-a]benzimidazole and 1-substituted 3-arylpyrazino-[1,2-a]benzimidazole derivatives were synthesized using 1-(2-arylethan-2-on)2-acylbenzimidazole derivatives as starting materials. Antifungal activities of the compounds obtained were examined in vitro.
