170033-47-3

Basic information

• Product Name: (R)-1-N-Boc-2-methylpiperazine
• Synonyms: (R)-TERT-BUTYL 2-METHYLPIPERAZINE-1-CARBOXYLATE;(R)-2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-2-METHYL-1-BOC-PIPERAZINE;(R)-1-N-BOC-2-METHYL PIPERAZINE;(2R)-2-Methylpiperazine, N1-BOC protected;tert-Butyl (2R)-2-methylpiperazine-1-carboxylate;(R)-1-Boc-2-methyl-piperazine;(N)-1-N-Boc-2-methyl-piperazine
• CAS NO: 170033-47-3
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.28
• Product Categories: pharmacetical;Pyrans, Piperidines &Piperazines;Piperaizine;Pyrans, Piperidines & Piperazines
• Mol File: 170033-47-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 34-36 °C
• Boiling Point: 268.7 °C at 760 mmHg
• Flash Point: 116.3 °C
• Appearance: /
• Density: 0.997 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.49±0.40(Predicted)
• CAS DataBase Reference: (R)-1-N-Boc-2-methylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-N-Boc-2-methylpiperazine(170033-47-3)
• EPA Substance Registry System: (R)-1-N-Boc-2-methylpiperazine(170033-47-3)

Safety Data

• Hazard Codes: Xi
• RIDADR: UN3077
• Hazardous Substances Data: 170033-47-3(Hazardous Substances Data)

Usage

Uses

(R)-1-Boc-2-methylpiperazine is a reagent in the synthesis of potent and bioavailable inhibitors of Na+/H+ enxchanger type 3 used in the treatment of sleep apneas.

InChI:InChI=1S/C10H20N2O2/c1-8-7-11-5-6-12(8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3

Upstream product

• 170033-58-6 tert-Butyl (R)-2-methyl-4-(phenylmethyl)-1-piperazinecarboxylate 
• 1217684-73-5 C₁₈H₂₆N₂O₄ 
• 170033-53-1 (R)-<2-<(2-Hydroxyethyl)(phenylmethyl)amino>-1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester 
• 170033-65-5 (R)-2-Amino-N-benzyl-N-(2-hydroxy-ethyl)-propionamide 
• 170033-55-3 (R)-3-Methyl-1-(phenylmethyl)piperazin-2-one 
• 132871-09-1 (R)-1-benzyl-3-methylpiperazine-2,5-dione 
• 153842-01-4 (R)-2-(2-Chloro-acetylamino)-propionic acid methyl ester 
• 132871-11-5 (R)-3-Methyl-1-(phenylmethyl)piperazine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1181076-84-5 N'-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-N-[(6-methyl-3'-{[(3R)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)methyl]-1,1-cyclopropanedicarboxamide 
• 1095539-51-7 (R)-tert-butyl 4-(3,4-dimethoxyphenyl)-2-methylpiperazine-1-carboxylate 
• 859517-93-4 4-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-2-(R)-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1095539-61-9 (R)-1-(4-cyclopropyl-3-methoxyphenyl)-3-methylpiperazine 

Relevant articles and documents

GLYCINE TRANSPORTER-1 INHIBITORS

The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

A novel and facile method to synthesize (R)- and (S)-2-methylpiperazine

A concise and efficient synthesis of (R)- and (S)-2-methylpiperazine in only five steps from (D)- and (L)-alanine is described. The key step is reaction of benzylamine with a bifunctional molecule to build a six-membered ring.

Imidazo[1,5-A]quinolines for treatment of anxiety and sleep disorders

Imidazo[1,5-a]quinolines of formula (I) which are useful pharmaceutical agents for the treatment of anxiety, sleep disorders, panic states, convulsions and muscle disorders. STR1