(3R,4S)-1-(4-Chlorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidine-2-one, also known as N-Des(4-Fluorophenyl)-N-(3-chlorophenyl)-ezetimibe, is a derivative of Ezetimibe (E975000). It is a complex organic compound with a unique molecular structure that features a combination of phenyl, hydroxypropyl, and azetidine moieties. (3R,4S)-1-(4-Chlorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidine-2-one is characterized by its stereochemistry, with the 3R and 4S configurations playing a crucial role in its properties and potential applications.
1700622-08-7
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Basic information
- Product Name: (3R,4S)-1-(4-chlorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one
- Synonyms: (3R,4S)-1-(4-chlorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one;Ezetimibe impurity 10;Ezetimibe Impurity J;Ezetimibe Impurity L
- CAS NO:1700622-08-7
- Molecular Formula: C24H21ClFNO3
- Molecular Weight: 425.8798432
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1700622-08-7.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 676.0±55.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.354±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 9.72±0.30(Predicted)
- CAS DataBase Reference: (3R,4S)-1-(4-chlorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one(CAS DataBase Reference)
- NIST Chemistry Reference: (3R,4S)-1-(4-chlorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one(1700622-08-7)
- EPA Substance Registry System: (3R,4S)-1-(4-chlorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one(1700622-08-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1700622-08-7(Hazardous Substances Data)
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1700622-08-7 Usage
Uses
1. Used in Pharmaceutical Industry:(3R,4S)-1-(4-Chlorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidine-2-one is used as an antihyperlipoproteinemic agent for the treatment of hyperlipidemia. It functions as a cholesterol absorption inhibitor, helping to regulate cholesterol levels in the body and reduce the risk of cardiovascular diseases.
2. Used in Drug Development:
As a derivative of Ezetimibe, (3R,4S)-1-(4-Chlorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidine-2-one may have potential applications in the development of new drugs targeting cholesterol-related conditions. Its unique structure and stereochemistry could offer novel mechanisms of action or improved efficacy compared to existing treatments.
3. Used in Research and Development:
The compound's complex structure and potential biological activities make it an interesting candidate for further research in the fields of medicinal chemistry and pharmacology. It could be studied for its interactions with various biological targets, potentially leading to the discovery of new therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1700622-08-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,7,0,0,6,2 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.Calculate Digit Verification of CAS Registry Number 1700622-08:
(9*1)+(8*7)+(7*0)+(6*0)+(5*6)+(4*2)+(3*2)+(2*0)+(1*8)=117
117 % 10 = 7
So 1700622-08-7 is a valid CAS Registry Number.
1700622-08-7Upstream product
1700622-08-7Downstream Products
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(3R,4S)-1-(4-chlorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one
