17009-95-9Relevant academic research and scientific papers
Chemistry of Pyrimidine. Proton Magnetic Resonance Study of Covalent Hydration Across the 3,4-Carbon-Nitrogen Bond of 5-Substituted Pyrimidines
Kress, Thomas J.
, p. 437 - 439 (2007/10/02)
Pyrimidines containing 5-substituents which are weakly or strongly electron withdrawing undergo covalent hydration across the 3,4-carbon-nitrogen bond in aqueous acid.The degree of hydration was measured by proton magnetic resonance spectroscopy and was found to be dependent on the strength of the acid media and the electron withdrawing power of the 5-substituent.
IONIC HYDROGEN BOND. 4. INTRAMOLECULAR AND MULTIPLE BONDS. PROTONATION AND COMPLEXES OF AMIDES AND AMINO ACID DERIVATIVES.
Meot-Ner (Mautner)
, p. 278 - 283 (2007/10/02)
The paper examines the proton affinities and ionic hydrogen bonding of some amides and of the N-acetylated amino acid derivative CH//3CONHCH(CH//3)COOCH//3. The thermochemistry of these species can serve as a model for the energetics of protonated intermediates in acid hydrolysis of amides and the energetics of protonated amide groups in proteins.
