1701-24-2

Basic information

• Product Name: 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE
• Synonyms: 2-TrifluoroMethyl-4-chloroquinoline;BUTTPARK 29\04-05;4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE;4-Chloro-2-(trifluoromethyl)quinoline 97%;4-Chloro-2-(trifluoromethyl)quinoline97%
• CAS NO: 1701-24-2
• Molecular Formula: C₁₀H₅ClF₃N
• Molecular Weight: 231.6
• Product Categories: Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Quinolines;QuinolinesHeterocyclic Building Blocks;Quinoline&Isoquinoline
• Mol File: 1701-24-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 31-33°C
• Boiling Point: 236.4 °C at 760 mmHg
• Flash Point: 225°C
• Appearance: /
• Density: 1.427 g/cm³
• Vapor Pressure: 0.0222mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.19±0.50(Predicted)
• CAS DataBase Reference: 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE(1701-24-2)
• EPA Substance Registry System: 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE(1701-24-2)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1701-24-2(Hazardous Substances Data)

Usage

General Description

4-Chloro-2-(trifluoromethyl)quinoline is a chlorinated quinoline derivative. It is a synthetic organic compound with the chemical formula C10H5ClF3N. It is a yellow crystalline solid that is insoluble in water but soluble in organic solvents. 4-Chloro-2-(trifluoromethyl)quinoline is used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active compounds. It has also been studied for its potential anti-inflammatory and anti-cancer properties. The presence of both a chloro and trifluoromethyl group in the molecule gives it unique chemical reactivity and makes it a useful intermediate for the production of other complex compounds.

InChI:InChI=1/C11H7ClF3N/c1-6-2-3-9-7(4-6)8(12)5-10(16-9)11(13,14)15/h2-5H,1H3

Upstream product

• 1701-18-4 2-(trifluoromethyl)quinolin-4-ol 
• 1034269-67-4 (1Z)-N-(2-ethynylphenyl)-2,2,2-trifluoroethanimidoyl chloride 
• 62-53-3 aniline 

Downstream Products

• 175203-79-9 4-(piperazin-1-yl)-2-(trifluoromethyl)quinolIne 
• 1701-33-3 4-azido-2-trifluoromethylquinoline 
• 1141427-69-1 4-(3-ethynylphenoxy)-2-(trifluoromethyl)quinoline 

Relevant articles and documents

2 -trifluoromethyl -4 - amino - quinoline derivative and application thereof

The invention discloses 2 -trifluoromethyl -4 - amino - quinoline derivatives and application thereof, and comprises a compound represented by the following general formula I. The prepared compound is used for preparing an anti-tumor active drug, has a go

Palladium-catalyzed chloroimination of imidoyl chlorides to a triple bond: An intramolecular reaction leading to 4-chloroquinolines

(Chemical Equation Presented) In this paper, a new type of effective chloroimination was reported. This reaction afforded 4-chloro-2-perfluoroalkyl quinolines from fluorinated imidoyl chlorides in high yields. This is the first achievement of oxidative addition-reductive elimination type C-Cl bond activation by chloropalladation.

Pesticides

Compound of the formula (I) are disclosed or a salt thereof, wherein Ar is an optionally substituted polycyclic ring system containing n rings, where n is the integer 2 or 3, at least n-1 rings being aromatic and containing one to three ring nitrogen atoms and optionally containing one or more additional heteroatoms; Q is an alkyl chain containing 1 to 12 carbon atoms and optionally containing a sulphur or one or two oxygen atoms; Q1 is a group (C(R2)=C(R3))a --(C(R4)=C(R5)) wherein a is 0 or 1, R2, R3, R4 and R5 are the same or different, at least two being hydrogen and the other two being independently selected from hydrogen, halo, C1-4 haloalkyl; X is oxygen or sulphur; and R1 is selected from hydrogen and C1-8 hydrocarbyl optionally substituted by dioxalanyl, halo, cyano, trifluoromethyl, trifluoromethylthio or C1-6 alkoxy are described which have activity particularly against arthropod pests. Pesticidal formulations containing the compounds of the formula (1), their use in the control of pests and method for their preparation are also disclosed.