1701-24-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-(trifluoromethyl)quinoline serves as a crucial building block in the synthesis of various biologically active compounds. Its unique chemical properties make it a versatile component in the development of new pharmaceuticals, particularly those with potential anti-inflammatory and anti-cancer properties.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 4-Chloro-2-(trifluoromethyl)quinoline is utilized as a key intermediate for the production of compounds with pesticidal or herbicidal activities, contributing to the development of effective crop protection agents.
Used in Chemical Synthesis:
4-Chloro-2-(trifluoromethyl)quinoline's unique reactivity, due to the presence of a chloro and trifluoromethyl group, positions 4-Chloro-2-(trifluoromethyl)quinoline as a useful intermediate for the production of other complex organic compounds in various chemical synthesis processes.

InChI:InChI=1/C11H7ClF3N/c1-6-2-3-9-7(4-6)8(12)5-10(16-9)11(13,14)15/h2-5H,1H3

Upstream product

• 1701-18-4 2-(trifluoromethyl)quinolin-4-ol 
• 1034269-67-4 (1Z)-N-(2-ethynylphenyl)-2,2,2-trifluoroethanimidoyl chloride 
• 62-53-3 aniline 

Downstream Products

• 124467-00-1 (2E/Z, 4E) N-Isobutyl 3-methyl-11-(2-trifluoromethyl-4-quinolinyloxy)undeca-2,4-dienamide 
• 1701-18-4 2-(trifluoromethyl)quinolin-4-ol 
• 1141427-69-1 4-(3-ethynylphenoxy)-2-(trifluoromethyl)quinoline 
• 1701-33-3 4-azido-2-trifluoromethylquinoline 
• 175203-79-9 4-(piperazin-1-yl)-2-(trifluoromethyl)quinolIne 

Relevant academic research and scientific papers

2 -trifluoromethyl -4 - amino - quinoline derivative and application thereof

The invention discloses 2 -trifluoromethyl -4 - amino - quinoline derivatives and application thereof, and comprises a compound represented by the following general formula I. The prepared compound is used for preparing an anti-tumor active drug, has a go

Investigations into the flexibility of the 3D structure and rigid backbone of quinoline by fluorine addition to enhance its blue emission

Achieving the desired structures of organic molecules for targeted applications is vital. Folding caused by weak intermolecular forces plays an important part in their 3D structure. Powerful tools which enable us to do this are currently under investigation by researchers across the globe. On this account, quinoline was chosen as a model scaffold because of its rigid 3D structure. Addition of fluorine was found to result in increased flexibility of the structure with a decrease in the number of intermolecular interactions. This resulted in improvement of their photophysics and blue emission. A total of 19 novel fluoroquinoline molecules were synthesised in order to carry out this study. Of these, grown crystals of 10 compounds were successfully achieved and used. In addition, characterisation techniques such as NMR, HRMS, UV-vis and computational techniques were used to explore the 3D structure of these molecules.

Palladium-catalyzed chloroimination of imidoyl chlorides to a triple bond: An intramolecular reaction leading to 4-chloroquinolines

(Chemical Equation Presented) In this paper, a new type of effective chloroimination was reported. This reaction afforded 4-chloro-2-perfluoroalkyl quinolines from fluorinated imidoyl chlorides in high yields. This is the first achievement of oxidative addition-reductive elimination type C-Cl bond activation by chloropalladation.

Potential Antimalarials. XVII. Di- and Mono-Mannich Bases of 2(and 4)-phenol

Di- and mono-Mannich base derivatives of 2(and 4)-phenols have been prepared for comparison with the 7-trifluoromethyl isomers in tests for antimalarial activity.The order of activity in in vitro tests against t