170117-06-3Relevant academic research and scientific papers
Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III
Webster, Caroline G.,Park, Hyeri,Ennis, Amanda F.,Hong, Jiyong
supporting information, (2021/04/22)
Rhodojaponin III is a grayanane-type diterpenoid natural product with a novel chemical scaffold. It shows potent antinociceptive activity and may represent a new class of natural non-opioid analgesics with a novel mode of action. We explored the Au(I)-cat
Enantiomerically Pure 6-Substituted 2-Oxo-cyclohexanecarboxylates by Conjugate Addition of Cuprates to Asymmetric Shielded 2-Oxo-cyclohexenecarboxylates
Urban, Ernst,Riehs, Gerhard,Knuehl, Guido
, p. 11149 - 11164 (2007/10/02)
Asymmetric shielded 2-oxo-cyclohexenecarboxylates 6n and 6x were prepared by transesterification of 2-oxo-cyclohexanecarboxylate 2 with camphor derived concave alcohols 1n and 1x and by subsequent introduction of a double bond via phenylselenides.Diastereoselective conjugate addition of equimolar amounts of mixed cuprates at -78 deg C and deprotection by methanolysis gave enantiomerically pure 6-substituted 2-oxo-cyclohexanecarboxylates 14-19 and ent-14-19, valuable as chiral building blocks in natural product synthesis.
EPC Synthesis of 6-Substituted 2-Oxo-cyclohexanecarboxylates via Conjugate Addition of Cuprates to Asymmetric Shielded 2-Oxo-cyclohexenecarboxylates
Urban, Ernst,Riehs, Gerhard,Knuehl, Guido
, p. 4773 - 4776 (2007/10/02)
Asymmetric shielded 2-oxo-cyclohexenecarboxylates 6n and 6x were prepared by transesterification of 2-oxo-cyclohexanecarboxylate 2 with camphor derived concave alcohols 1n and 1x and by subsequent introduction of a double bond via phenylselenides.Diastere
