170211-83-3

Upstream product

• 4840-68-0 2-hydroxy-1-cyclohexenecarboxylic acid ethyl ester 
• 87420-26-6 (1R,2S,3R)-3-[N-Phenylsulfonyl-N-(3,5-dimethylphenyl)amino]bornan-2-ol 

Downstream Products

• 172926-64-6 (1R,2S,3R,4S)-<3--2-bornyl>-(1R,6S)-6-butyl-2-oxo-cyclohexanecarboxylate 
• 172926-65-7 (1R,2S,3R,4S)-<3--2-bornyl>-(1R,6S)-6-tert-butyl-2-oxo-cyclohexanecarboxylate 
• 172926-63-5 (1R,2S,3R,4S)-<3--2-bornyl>-(1R,6S)-6-methyl-2-oxo-cyclohexanecarboxylate 
• 170211-89-9 (1R,2S,3R,4S)-<3--2-bornyl>-(6R)-2-hydroxy-6-phenyl-cyclohexenecarboxylate 
• 170211-88-8 (1R,2S,3R,4S)-<3--2-bornyl>-(6R)-2-hydroxy-6-isopropenyl-cyclohexenecarboxylate 
• 170211-87-7 (1R,2S,3R,4S)-<3--2-bornyl>-(6R)-2-hydroxy-6-vinyl-cyclohexenecarboxylate 
• 170211-93-5 (1R,2S,3R,4S)-<3--2-bornyl>-2-oxo-cyclohexenecarboxylate 

Relevant academic research and scientific papers

EPC Synthesis of 6-Substituted 2-Oxo-cyclohexanecarboxylates via Conjugate Addition of Cuprates to Asymmetric Shielded 2-Oxo-cyclohexenecarboxylates

Asymmetric shielded 2-oxo-cyclohexenecarboxylates 6n and 6x were prepared by transesterification of 2-oxo-cyclohexanecarboxylate 2 with camphor derived concave alcohols 1n and 1x and by subsequent introduction of a double bond via phenylselenides.Diastere

Enantiomerically Pure 6-Substituted 2-Oxo-cyclohexanecarboxylates by Conjugate Addition of Cuprates to Asymmetric Shielded 2-Oxo-cyclohexenecarboxylates

Asymmetric shielded 2-oxo-cyclohexenecarboxylates 6n and 6x were prepared by transesterification of 2-oxo-cyclohexanecarboxylate 2 with camphor derived concave alcohols 1n and 1x and by subsequent introduction of a double bond via phenylselenides.Diastereoselective conjugate addition of equimolar amounts of mixed cuprates at -78 deg C and deprotection by methanolysis gave enantiomerically pure 6-substituted 2-oxo-cyclohexanecarboxylates 14-19 and ent-14-19, valuable as chiral building blocks in natural product synthesis.