170229-79-5

Upstream product

• 2008-75-5 N-chloroethylpiperidine hydrochloride 
• 636-93-1 5-nitroguaiacol 
• 399579-80-7 1-[2-(2-methoxy-5-nitro-phenoxy)-ethyl]-piperidine 

Downstream Products

• 399579-82-9 (2,2-dimethoxy-ethyl)-[4-methoxy-3-(2-piperidin-1-yl-ethoxy)-phenyl]-amine 
• 777860-03-4 C₂₂H₂₃FN₂O₄ 
• 619254-52-3 2-(4-chloro-phenyl)-pent-4-enoic acid (4-methoxy-3-[2-(4-piperidin-1-yl)-ethoxy]-phenyl)-amide 
• 619254-68-1 2-(3-chloro-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-piperidin-1-yl-ethoxy)-phenyl]-amide 
• 907209-25-0 C₂₅H₃₁BrN₂O₃ 
• 907209-24-9 C₂₆H₃₄N₂O₃ 
• 907209-23-8 C₂₆H₃₁F₃N₂O₃ 
• 619254-73-8 2-(4-fluoro-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-piperidin-1-yl-ethoxy)-phenyl]-amide 
• 907209-14-7 C₂₅H₃₀Cl₂N₂O₃ 
• 619254-71-6 2-(3-trifluoromethyl-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-piperidin-1-yl-ethoxy)-phenyl]-amide 
• 619254-27-2 2-(3-fluoro-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-piperidin-1-yl-ethoxy)-phenyl]-amide 
• 619254-41-0 5-(tert-butyl-dimethyl-silanyloxy)-2-(3,4-dichloro-phenyl)-pentanoic acid [4-methoxy-3-(2-piperidin-1-yl-ethoxy)-phenyl]-amide 
• 561277-11-0 3-(3,5-difluoro-phenyl)-1-(2,2-dimethoxy-ethyl)-1-[4-methoxy-3-(2-piperidin-1-yl-ethoxy)-phenyl]-urea 
• 561277-10-9 1-(2,2-dimethoxy-ethyl)-3-(3-fluoro-phenyl)-1-[4-methoxy-3-(2-piperidin-1-yl-ethoxy)-phenyl]-urea 

Relevant academic research and scientific papers

A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists

Bisaryl cyclic ureas have been identified as high affinity 5-HT 2C receptor antagonists with selectivity over 5-HT2A and 5-HT2B. Compounds such as 8 and 22 have shown oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function in rodents.

COMPOUNDS HAVING ACTIVITY AT 5HT2C RECEPTOR AND USES THEREOF

Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein Q is phenyl or a 6-membered heteroaromatic group containing at least one nitrogen atom; A is -(CH2-CH2)-, -(CH=CH)-, -(CH2)

COMPOUNDS HAVING ACTIVITY AT 5HT2C RECEPTOR AND USES THEREOF

Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein R1 is halogen, cyano, C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkyloxy, C1-6alkoxy, C1 6alkylthio, hydroxy, amino, mono or di C1 6alkylamino, an N-linked 4 to 7 memb