170230-35-0

Upstream product

• 142-25-6 N,N',N'-trimethylenediamine 
• 5197-28-4 2-bromo-4-nitroanisole 
• 170230-34-9 N¹-(2-methoxy-5-nitrophenyl)-N¹, N², N²-trimethylethane-1,2-diamine 

Downstream Products

• 943519-48-0 N¹-(5-isothiocyanato-2-methoxyphenyl)-N¹, N², N²-trimethylethane-1,2-diamine 
• 1050501-38-6 C₂₃H₃₃N₅O₄S 

Relevant academic research and scientific papers

Method for treating proliferative disorders associated with mutations in c-Met

The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating c-Met associated cancers, in a subject in need thereof.

METHOD FOR INHIBITING TOPOISOMERASE II

The present invention relates to compounds that inhibit the activity of Hsp90 and inhibit topoisomerase II.

Method for treating proliferative disorders associated with protooncogene products

The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating Bcr-Abl, FLT-3, EGFR, c-Kit, B-raf, and NPM-ALK associated cancers, in a subject in need thereof.

METHOD FOR TREATING INFLAMMATORY DISORDERS

The present invention relates to a method for suppressing the immune system in a subject in need thereof, and a method for treating an inflammatory or immune disorder in a subject in need thereof.

METHOD FOR TREATING INFECTIONS

The present invention relates to compounds that inhibit the activity of Hsp90 and methods of using these compounds for treating or preventing infection.

METHOD FOR TREATING NON-HODGKIN'S LYMPHOMA

The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating non-Hodgkin's lymphoma, in a subject in need thereof.

Triazole compounds that modulate HSP90 activity

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.