170233-98-4

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 3699-66-9 ethyl 2-diethoxyphosphorylpropionate 
• 590365-65-4 triethyl 2-methyl-3-oxo-5-phenyl-2-phosphonopentanoate 

Relevant academic research and scientific papers

Palladium-catalyzed oxidative cyclizations: Synthesis of dihydropyranones and furanones

A boron-mediated syn- and anti-stereoselective aldol reaction giving rise to various β-hydroxyenones was coupled to a Pd(II)-mediated oxidative cyclization to give 2,3,6-trisubstituted syn- and antidihydropyranones in good yields. The Pd(I

Tandem reduction-olefination for the stereoselective synthesis of (Z)-α-fluoro-α,β-unsaturated esters

A tandem stereoselective reduction-olefination reaction of ethyl 2-acyl-2-fluoro-2-diethylphosphonoacetate employing NaBH4 in EtOH was developed. The one-pot reaction gave α-fluoro-α,β-unsaturated esters with excellent (Z)-selectivity. A plausible mechanism involving a diastereoselective reduction predicted by the Felkin-Anh model, followed by olefination similar to the Horner-Wadsworth-Emmons reaction, has been proposed.