170291-48-2

Upstream product

• 95299-16-4 methyl [3,5-bis(trifluoromethyl)-phenyl]-acetate 
• 36982-84-0 2,4,6-Triisopropylbenzenesulfonyl azide 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 

Downstream Products

• 170291-46-0 methyl 2-[(N-tert-butoxycarbonyl-4-phenylpiperidin-4-yl)methoxy]-2-(3,5-bis(trifluoromethyl)phenyl)acetate 
• 170291-50-6 N-{2-[(N-tert-butoxycarbonyl-4-phenylpiperidin-4-yl)methoxy]-2-(3,5-bis(trifluoromethyl)phenyl)acetyl}-4(R)-benzyl-2-oxazolidinone 
• 1025823-00-0 4-[(3,5-bis-trifluoromethyl-phenyl)-chlorocarbonyl-methoxymethyl]-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 170291-49-3 2-(1-tert-Butoxycarbonyl-4-phenylpiperidine-4-yl)methoxy-2-(3,5-bis(trifluoromethyl)phenyl)acetic acid 

Relevant academic research and scientific papers

TAK1 KINASE INHIBITORS, COMPOSITIONS, AND USED RELATED THERETO

The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula (I), pharmaceutical compositions having a compound of formula (I), and methods of treating or prevent

1-AMIDO-4-PHENYL-4-BENZYLOXYMETHYL-PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS AS NEUROKININ-1(NK-1) ANTAGONISTS FOR THE TREATMENT OF EMESIS, DEPRESSION, ANXIETY AND COUGH

Disclosed are NK1 antagonists having the formula: Also disclosed are uses of compounds of formula (I) for the manufacture of a medicament for treating a number of physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

Gem-disubstituted azacyclic tachykinin antagonists

The present invention is directed to certain compounds represented by structural formula I: STR1 or a pharmaceutically acceptable salt thereof wherein R 1, R 2, R 3, R 4, R 5, R 6, R 7, A 1, A 2, X, m and n are defined herein. The compounds of this invention are tachykinin receptor antagonists and are of particular use in the treatment of pain, inflammation, migraine and emesis.

Aralkoxy and aralkylthio substituted azacyclic compounds as tachykinin antagonists

The present invention relates to compounds of formula (I) wherein n is 3 and where any carbon atom of (CH2)n may be substituted by R4 and/or R5 ; X represents O or S; R1 represents (CH2)su