170305-15-4Relevant academic research and scientific papers
Preparation of α- and β-substituted alanine derivatives by α-amidoalkylation or Michael addition reactions under heterogeneous catalysis assisted by microwave irradiation
De la Hoz,Díaz-Ortiz,Gómez,Mayoral,Moreno,Sánchez-Migallón,Vázquez
, p. 5421 - 5428 (2001)
Silica-supported Lewis acids are useful catalysts in conjunction with microwave irradiation for the synthesis of a range of alanine derivatives. Reaction of methyl α-acetamidoacrylate (1) with different heterocycles, such as furan (2), pyrrole (3), N-benzylpyrrole (4), indole (5) and pyrazole (6) and the carbocycle 1,3,5-trihydroxybenzene (7), led to several α-amino acid precursors.
FeCl3-catalyzed conjugate addition of secondary amines, imidazole and pyrazole to methyl-2-acetamidoacrylate. Preparation of β-dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives
Perez,Pleixats
, p. 8355 - 8362 (2007/10/02)
β-Dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives are obtained by conjugate addition of nitrogen based nucleophiles (cyclic and acyclic secondary amines, imidazole and pirazole) to methyl 2-acetamidoacrylate 1, under iron(III) chloride catalysis.
