170309-75-8Relevant academic research and scientific papers
Synthesis, structure, and biological activity of mixed-ligand platinum(II) complexes with aminonitroxides
Sen',Rukina,Tkachev,Pis'menskii,Volkova,Goncharova,Raevskaya,Tikhomirov,Gorbacheva,Konovalova
, p. 1613 - 1619 (2008/10/08)
Mixed-ligand platinum complexes cis-PtII(R6NH2)(NH3)X2 and cis-PtII(R5NH2)(NH3)X2 (R6 is 2,2,6,6-tetramethyl-4-piperidyl-1-oxyl and R5 is 2,2,5,5-tetramethyl-3-pyrrolidinyl-1-oxyl) were synthesized by either the reaction of aminonitroxides RNH2 with Na[PtII(NH3)Cl2I] generated in situ (for X2 = CII) or by replacement of the iodo-chloro ligands in cis-PtII(RNH2)(NH3)CII by dichloro and oxalato ligands. The complexes obtained were characterized by elemental analysis and by IR, UV, and ESR spectra. For cis-PtII(R5NH2)(NH3)Cl2, crystal and molecular structures were determined by X-ray diffraction analysis. Cisplatin accelerates autooxidation of methyl linoleate and the platinum nitroxide complexes synthesized exhibit antioxidant properties. The rate of isolated DNA binding with the new complexes is almost as high as that for cisplatin. cis-Pt11(R6NH2)(NH3)Cl2 exhibits the highest antitumor activity. The high antitumor activity of platinum nitroxide complexes shows that the possible radical component is not a crucial factor in the cytotoxic action of cisplatin.
