170366-90-2 Usage
Uses
Used in Pharmaceutical Research:
Ethanone, 2,2,2-trifluoro-1-(1H-indol-5-yl)(9CI) is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Organic Synthesis:
In the field of organic synthesis, Ethanone, 2,2,2-trifluoro-1-(1H-indol-5-yl)(9CI) serves as a versatile building block for the creation of complex organic molecules. Its trifluoromethyl and indol-5-yl groups can be further modified or used as starting points for the synthesis of a wide range of compounds with diverse applications.
Used in Drug Discovery:
Ethanone, 2,2,2-trifluoro-1-(1H-indol-5-yl)(9CI) is utilized in drug discovery processes to identify and optimize potential drug candidates. Its unique structure and pharmacological properties make it a promising starting point for the development of new therapeutic agents.
Used in Medicinal Chemistry:
In medicinal chemistry, Ethanone, 2,2,2-trifluoro-1-(1H-indol-5-yl)(9CI) is employed as a structural motif for the design and synthesis of bioactive molecules. Its presence in various compounds can contribute to their biological activity, making it an important component in the development of novel therapeutic agents.
Used in Chemical Biology:
Ethanone, 2,2,2-trifluoro-1-(1H-indol-5-yl)(9CI) is also used in chemical biology to study the interactions between small molecules and biological targets. Its unique structure allows for the investigation of molecular recognition and signaling pathways, providing valuable insights into the development of new drugs and therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 170366-90-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,3,6 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 170366-90:
(8*1)+(7*7)+(6*0)+(5*3)+(4*6)+(3*6)+(2*9)+(1*0)=132
132 % 10 = 2
So 170366-90-2 is a valid CAS Registry Number.
170366-90-2Relevant articles and documents
Comprehensive synthesis of photoreactive (3-trifluoromethyl)diazirinyl indole derivatives from 5- and 6-trifluoroacetylindoles for photoaffinity labeling
Murai, Yuta,Sakihama, Yasuko,Hashidoko, Yasuyuki,Hashimoto, Makoto,Hatanaka, Yasumaru,Masuda, Katsuyoshi
, p. 8581 - 8587,7 (2012)
5- and 6-trifluoromethyldiazirinyl indoles were synthesized from corresponding bromoindole derivatives for the first time. They acted as mother skeletons for the comprehensive synthesis of various bioactive indole metabolites. These can be used in biologi
Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature
Ban, Shu-Rong,Cao, Ya-Fang,Dai, Hui-Xiong,Wang, Xing,Xu, Hui,Yi, Xing
supporting information, (2020/03/23)
A palladium-catalyzed fluoroacylation of (hetero)aryl boronic acid with the fluorothioacetates is described at ambient temperature. A variety of aryl, and heteroaryl boronic acids are compatible in the reaction, affording the corresponding fluoroalkyl ketones in moderate to good yields. Further late-stage di-, and trifluoroacylation of drug molecule clofibrate and estrone demonstrated the synthetic practicability of this protocol.2009 Elsevier Ltd. All rights reserved.
Indol-containing beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions
-
Page/Page column 14, (2010/11/27)
The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 and R2 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates,
Synthetic studies on trifluoroacetylindoles
Takami, Hitoshi,Koshimura, Hirokazu,Kumazawa, Toshiaki
, p. 1119 - 1124 (2007/10/03)
Trifluoroacetylindoles were obtained regioselectively through the reaction of indolylorganometallic species, prepared by halogen-metal exchange or direct metalation of N-substituted or -nonsubstituted indoles, with TFAA in good yield.
