170366-90-2

Usage

Uses

Used in Pharmaceutical Research:
Ethanone, 2,2,2-trifluoro-1-(1H-indol-5-yl)(9CI) is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Organic Synthesis:
In the field of organic synthesis, Ethanone, 2,2,2-trifluoro-1-(1H-indol-5-yl)(9CI) serves as a versatile building block for the creation of complex organic molecules. Its trifluoromethyl and indol-5-yl groups can be further modified or used as starting points for the synthesis of a wide range of compounds with diverse applications.
Used in Drug Discovery:
Ethanone, 2,2,2-trifluoro-1-(1H-indol-5-yl)(9CI) is utilized in drug discovery processes to identify and optimize potential drug candidates. Its unique structure and pharmacological properties make it a promising starting point for the development of new therapeutic agents.
Used in Medicinal Chemistry:
In medicinal chemistry, Ethanone, 2,2,2-trifluoro-1-(1H-indol-5-yl)(9CI) is employed as a structural motif for the design and synthesis of bioactive molecules. Its presence in various compounds can contribute to their biological activity, making it an important component in the development of novel therapeutic agents.
Used in Chemical Biology:
Ethanone, 2,2,2-trifluoro-1-(1H-indol-5-yl)(9CI) is also used in chemical biology to study the interactions between small molecules and biological targets. Its unique structure allows for the investigation of molecular recognition and signaling pathways, providing valuable insights into the development of new drugs and therapeutic strategies.

Upstream product

• 10075-50-0 5-bromo-1H-indole 
• 76-05-1 trifluoroacetic acid 
• 407-25-0 trifluoroacetic anhydride 
• 340-07-8 N-(trifluoroacetyl)piperidine 
• 181820-18-8 S-(tert-butyl)trifluorothioacetate 
• 144104-59-6 1H-indole-5-boronic acid 

Downstream Products

• 170366-91-3 2,2,2-trifluoro-1-[1-di(4-fluorophenyl)methylindol-5-yl]-1-ethanone 

Relevant academic research and scientific papers

Comprehensive synthesis of photoreactive (3-trifluoromethyl)diazirinyl indole derivatives from 5- and 6-trifluoroacetylindoles for photoaffinity labeling

5- and 6-trifluoromethyldiazirinyl indoles were synthesized from corresponding bromoindole derivatives for the first time. They acted as mother skeletons for the comprehensive synthesis of various bioactive indole metabolites. These can be used in biologi

Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature

A palladium-catalyzed fluoroacylation of (hetero)aryl boronic acid with the fluorothioacetates is described at ambient temperature. A variety of aryl, and heteroaryl boronic acids are compatible in the reaction, affording the corresponding fluoroalkyl ketones in moderate to good yields. Further late-stage di-, and trifluoroacylation of drug molecule clofibrate and estrone demonstrated the synthetic practicability of this protocol.2009 Elsevier Ltd. All rights reserved.

Indol-containing beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions

The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 and R2 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates,

Synthetic studies on trifluoroacetylindoles

Trifluoroacetylindoles were obtained regioselectively through the reaction of indolylorganometallic species, prepared by halogen-metal exchange or direct metalation of N-substituted or -nonsubstituted indoles, with TFAA in good yield.