17037-08-0Relevant articles and documents
TANKYRASE INHIBITORS
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Page/Page column 99, (2014/06/24)
The present invention relates to a compound of formula I wherein X is C(R6) or N, Y is C or N, and ring A, ring B, R1 and R2 have the meanings defined herein, provided that when ring B is carbocyclic, X is C(R6); or a pharmaceutically acceptable salt or solvate thereof. The compounds are tankyrase-1 and tankyrase-2 inhibitors and are useful in the treatment of a number of conditions, including cancer.
Dehydrogenation of 6-Azaquinazoline Derivatives. Formation of Unexpected Quinonediimine Intermediates
Huber, Imre,Fueloep, Ferenc,Lazar, Janos,Bernath, Gabor,Toth, Gabor
, p. 157 - 162 (2007/10/02)
2,6-Disubstituted 5,6,7,8-tetrahydropyridopyrimidin-4(3H)-one (6-azaquinazoline) derivatives 7a-e were synthesized from N-substituted 3-methoxycarbonyl-4-piperidones 5a, b and amidines 6a-c.Compounds 7a-d and the debenzylated derivatives 8a-c under