170373-80-5

Upstream product

• 139123-74-3 3',5'-O-tetraisopropyldisiloxane-1,3-diyl-2'-O-(phenoxythiocarbonyl)-2-azainosine 
• 139137-03-4 3',5'-O-tetraisopropyldisiloxane-1,3-diyl-2-azainosine 
• 36519-16-1 7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one 
• 1053247-31-6 3-(2-Nitro-benzyl)-7-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-3,7-dihydro-imidazo[4,5-d][1,2,3]triazin-4-one 

Downstream Products

• 171614-01-0 5'-O-(dimethoxytrityl)-N¹-(2-nitrobenzyl)-2-aza-2'-deoxyinosine 

Relevant academic research and scientific papers

Synthesis and biophysical and biological properties of oligonucleotides containing 2-aza-2'-deoxyinosine

The preparation of oligonucleotides containing 2-aza-2'-deoxyinosine is described. Protection of the 2-azahypoxanthine moiety with the photolabile 2-nitrobenzyl group enabled us to obtain the phosphoramidite derivative and oligonucleotides containing protected 2-aza-2'-deoxyinosine. After purification, photolysis of the oligonucleotides containing the protected analogue provided the desired oligonucleotides in good yields. Melting curves of duplexes containing 2-azahypoxanthine paired with the four natural bases at pH 6 and pH 8 proved that 2-azahypoxanthine base pairs were less stable than perfectly matched duplexes but showed little variation among different bases.