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Usage

Uses

Used in Cosmetics and Personal Care Products:
4-Imidazolidinone is used as a preservative in cosmetics and personal care products to prevent the growth of bacteria, fungi, and yeast, ensuring the safety and longevity of these products for consumers.
Used in Pharmaceuticals:
In the pharmaceutical industry, 4-Imidazolidinone is used as a preservative in various formulations to maintain the sterility and stability of the products, preventing microbial contamination and ensuring their efficacy and safety for use.
Despite its widespread use, the safety of 4-Imidazolidinone has been a topic of ongoing debate and scrutiny. Some individuals have reported allergic reactions to the compound, and there are concerns about its potential long-term effects on human health. As a result, various health and safety agencies have been closely monitoring its use and have implemented regulations to ensure its safe application in consumer products.

Upstream product

• 114981-11-2 1-benzyl-4-imidazolidinone 
• 100060-75-1 4-oxo-imidazolidine-1-carboxylic acid benzyl ester 

Downstream Products

• 1266519-59-8 1-({4-(3-chlorophenyl)-5-[3-(trifluoromethyl)phenyl]-1,3-thiazole-2-yl}carbonyl)imidazolidin-4-one 
• 1232069-32-7 1-{[4-Bromo-5-(3-chlorophenyl)thiophen-2-yl]carbonyl}imidazolidin-4-one 
• 1232068-48-2 3-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile 
• 1232069-08-7 1-{[5-Bromo-4-(3-chlorophenyl)thiophen-2-yl]carbonyl}imidazolidin-4-one 
• 1187919-39-6 1-({5-[3-(benzyloxy)phenyl]-1-(3-chlorophenyl)-1H-pyrazol-3-yl}carbonyl)imidazolidin-4-one 
• 1187917-12-9 AIC-292 

Relevant academic research and scientific papers

A Short Synthesis of 4-Imidazolidinone

A gram-scale, convenient, and simple synthesis of 4-imidazolidinone (1a) is described.Starting from the readily available glycinamide, 1a is obtained for the first time in a pure, solid form.

FIRST SYNTHESIS OF 40IMIDAZOLIDINONE

First synthesis of 4-imidazolidinone has been achieved via Beckman rearrangement of 1-alkoxycarbonylazetidin-3-one oxime sulfonates with alumina, followed by removal of the alkoxycarbonyl groups.