170454-77-0Relevant articles and documents
A new approach to the synthesis of di- and tripeptides with unnatural amino acids using organozinc chemistry
Dunn, Michael J.,Jackson, Richard F. W.
, p. 13905 - 13914 (1997)
Di- and tripeptides which incorporate an iodoalanine unit at the C-terminus can be converted into the corresponding organozinc reagents upon treatment with activated zinc. These C-terminal di- and tripeptide organozinc reagents react with electrophiles either under palladium catalysis, or by prior transmetallation to a zinc/copper reagent, to give di- and tripeptides incorporating non-proteinogenic amino acids without loss of stereochemical purity.