170464-97-8Relevant academic research and scientific papers
Discovery of novel 2-anilinopyrazolo[1,5-a]pyrimidine derivatives as c-Src kinase inhibitors for the treatment of acute ischemic stroke
Mukaiyama, Harunobu,Nishimura, Toshihiro,Shiohara, Hiroaki,Kobayashi, Satoko,Komatsu, Yoshimitsu,Kikuchi, Shinji,Tsuji, Eiichi,Kamada, Noboru,Ohnota, Hideki,Kusama, Hiroshi
, p. 881 - 889 (2008/02/08)
We synthesized a series of novel 2-anilinopyrazolo[1,5-a]pyrimidine derivatives and evaluated their ability to inhibit c-Src kinase; 7-(2-amino-2-methylpropylamino)-5-cyclopropyl-2-(3,5-dimethoxyphenylamino) pyrazolo-[1,5-a]pyrimidine-3-carboxamide 7o and
Synthesis and antimalarial activity of substituted pyrazole derivatives
Dominguez, Jose N.,Charris, Jaime E.,Caparelli, Mario,Riggione, Flavia
, p. 482 - 488 (2007/10/03)
The development of new antimalarial drugs is an urgent priority considering the increasing prevalence of drug-resistant Plasmodium falciparum parasites. A series of pyrazoles are described as part of efforts directed toward the synthesis of some potent an
Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines
Traxler, Peter,Bold, Guido,Frei, Joerg,Lang, Marc,Lydon, Nicholas,Mett, Helmut,Buchdunger, Elisabeth,Meyer, Thomas,Mueller, Marcel,Furet, Pascal
, p. 3601 - 3616 (2007/10/03)
In the course of the random screening of a pool of CIBA chemicals, the two pyrazolopyrimidines 1 and 2 have been identified as fairly potent inhibitors of the EGF-R tyrosine kinase. Using a pharmacophore model for ATP- competitive inhibitors interacting w
Studies on Activated Nitriles: Synthesis of New 3-Cyano-2-(3-Tolylamino)pyrazolopyrimidines
Ammar, Y. A.,El-Sharief, A. M. Sh.,Zahran, M. A.,El-Said, M. Z.,El-Said, U. H.
, p. 324 - 325 (2007/10/03)
Novel 3-cyano-2-(3-tolylamino)pyrazolopyrimidines have been synthesized using 5-amino-4-cyanopyrazole as starting material.
